Receptor tyrosine kinase MET ligand-interaction classified via machine learning from single-particle tracking data

Sebastian Malkusch, Johanna V. Rahm, Marina S. Dietz, Mike Heilemann, Jean-Baptiste Sibarita, Jörn Lötsch
MBoC. 2022-05-15; 33(6):
DOI: 10.1091/mbc.e21-10-0496

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Internalin B-mediated activation of the membrane-bound receptor tyrosine kinase MET is accompanied by a change in receptor mobility. Conversely, MET receptor mobility can be used to determine reproducibly whether a cell has been treated with internalin B, using machine learning algorithms trained on single-particle tracking data.

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