Rat genomics applied to psychiatric research.

1. Methods Mol Biol. 2010;597:357-88. doi: 10.1007/978-1-60327-389-3_25.

Rat genomics applied to psychiatric research.

Moisan MP(1), Ramos A.

Author information:
(1)INRA, UMR 1286 PsyNuGen, CNRS, UMR 5226, Université de Bordeaux 2, Bordeaux,
France.

Psychiatric diseases are very debilitating and some of them highly prevalent
(e.g., depression or anxiety). The rat remains one model of choice in this
discipline to investigate the neural mechanisms underlying normal and
pathological traits. Genomic tools are now applied to identify genes involved in
psychiatric illnesses and also to provide new biomarkers for diagnostic and
prognosis, new targets for treatment and more generally to better understand the
functioning of the brain. In this report, we will review rat models, behavioral
approaches used to model psychiatry-related traits and the major studies
published in the field including genetic mapping of quantitative trait loci
(QTL), transcriptomics, proteomics and transgenic models.

DOI: 10.1007/978-1-60327-389-3_25
PMID: 20013246 [Indexed for MEDLINE]

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