Quantitative trait Loci influencing abdominal fat deposition and functional variability of the HPA axis in the rat.
Horm Metab Res. 2014-07-08; 46(09): 635-643
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1. Horm Metab Res. 2014 Aug;46(9):635-43. doi: 10.1055/s-0034-1383574. Epub 2014 Jul
Quantitative trait Loci influencing abdominal fat deposition and functional
variability of the HPA axis in the rat.
Marissal-Arvy N(1), Heliès JM(1), Tridon C(1), Moisan MP(1), Mormède P(1).
(1)INRA, Laboratory of Nutrition and Integrative Neurobiology, Bordeaux Cedex,
With the aim to reveal common genomic regions influencing phenotypes related to
HPA axis function and metabolism, we did a quantitative trait loci (QTL) study in
a F2 population obtained from the cross-breeding between 2 contrasted rat
strains, LOU/C and Fischer 344. QTL determining phenotypes related first to
corticotropic function were searched: plasma corticosterone (Cort) in control and
stress conditions, after a dexamethasone suppression treatment (glucocorticoid
receptor related-effect), and mineralocorticoid receptor-mediated urinary
response to aldosterone. Then, phenotypes related to metabolism were studied on
the same animals: body composition, basal and post-insulin plasma glucose, plasma
free fatty acids, leptin, and insulin. Finally, we analyzed the overlapping
regions between these QTL and looked for candidate genes within these regions.
The gene NR3C1 encoding the glucocorticoid receptor was confirmed to be central
in the link between hypothalamic-pituitary-adrenal (HPA) axis function and fat
deposition, and its metabolic consequences. Among the other candidate genes
detected, most contain a glucocorticoid responsive element, strengthening our
hypothesis of common genetic determinism between HPA axis and metabolism.
© Georg Thieme Verlag KG Stuttgart · New York.
PMID: 25003539 [Indexed for MEDLINE]