Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus.

V. Lemaire, M. Koehl, M. Le Moal, D. N. Abrous
Proceedings of the National Academy of Sciences. 2000-09-26; 97(20): 11032-11037
DOI: 10.1073/pnas.97.20.11032

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Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11032-7.

Lemaire V, Koehl M, Le Moal M, Abrous DN.

Early experiences such as prenatal stress significantly influence the development of the brain and the organization of behavior. In particular, prenatal stress impairs memory processes but the mechanism for this effect is not known. Hippocampal granule neurons are generated throughout life and are involved in
hippocampal-dependent learning. Here, we report that prenatal stress in rats induced lifespan reduction of neurogenesis in the dentate gyrus and produced impairment in hippocampal-related spatial tasks. Prenatal stress blocked the increase of learning-induced neurogenesis. These data strengthen pathophysiological hypotheses that propose an early neurodevelopmental origin for psychopathological vulnerabilities in aging.

DOI: 10.1073/pnas.97.20.11032
PMID: 11005874

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