Prefrontal involvement related to cognitive impairment in progressive muscular atrophy.
Neurology. 2014-07-30; 83(9): 818-825
DOI: 10.1212/wnl.0000000000000745
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1. Neurology. 2014 Aug 26;83(9):818-25. doi: 10.1212/WNL.0000000000000745. Epub 2014
Jul 30.
Prefrontal involvement related to cognitive impairment in progressive muscular
atrophy.
Raaphorst J(1), van Tol MJ(2), Groot PF(2), Altena E(2), van der Werf YD(2),
Majoie CB(2), van der Kooi AJ(2), van den Berg LH(2), Schmand B(2), de Visser
M(2), Veltman DJ(2).
Author information:
(1)From the Departments of Neurology (J.R., A.J.v.d.K., B.S., M.d.V.) and
Radiology (P.F.C.G., C.B.M.), Academic Medical Center, University of Amsterdam;
Departments of Psychiatry (D.J.V.) and Anatomy and Neurosciences (Y.D.v.d.W.), VU
University Medical Centre, Amsterdam; Department of Psychology (B.S.), University
of Amsterdam; Neuroimaging Center (M.-J.v.T.), University Medical Center
Groningen, University of Groningen; Brain Center Rudolf Magnus Institute of
Neuroscience (L.H.v.d.B), Department of Neurology, University Medical Center
Utrecht; Netherlands Institute for Neuroscience (E.A., Y.D.v.d.W.), an Institute
of the Royal Netherlands Academy of Arts and Sciences, Amsterdam; Department of
Neurology (J.R.), Radboud University Medical Center Nijmegen, the Netherlands;
and Department of Clinical Neurosciences (E.A.), University of Cambridge, UK.
.
(2)From the Departments of Neurology (J.R., A.J.v.d.K., B.S., M.d.V.) and
Radiology (P.F.C.G., C.B.M.), Academic Medical Center, University of Amsterdam;
Departments of Psychiatry (D.J.V.) and Anatomy and Neurosciences (Y.D.v.d.W.), VU
University Medical Centre, Amsterdam; Department of Psychology (B.S.), University
of Amsterdam; Neuroimaging Center (M.-J.v.T.), University Medical Center
Groningen, University of Groningen; Brain Center Rudolf Magnus Institute of
Neuroscience (L.H.v.d.B), Department of Neurology, University Medical Center
Utrecht; Netherlands Institute for Neuroscience (E.A., Y.D.v.d.W.), an Institute
of the Royal Netherlands Academy of Arts and Sciences, Amsterdam; Department of
Neurology (J.R.), Radboud University Medical Center Nijmegen, the Netherlands;
and Department of Clinical Neurosciences (E.A.), University of Cambridge, UK.
OBJECTIVE: To examine brain activation patterns during verbal fluency performance
in patients with progressive muscular atrophy (PMA) and amyotrophic lateral
sclerosis (ALS).
METHODS: fMRI was used to examine the blood oxygen level-dependent response
during letter and category fluency performance in 18 patients with PMA, 21
patients with ALS, and 17 healthy control subjects, matched for age and
education. fMRI results are reported at p