Postoperative recovery of hippocampal contralateral diffusivity in medial temporal lobe epilepsy correlates with memory functions
Journal of Neurology, Neurosurgery & Psychiatry. 2010-06-20; 82(3): 340-343
DOI: 10.1136/jnnp.2008.158428
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1. J Neurol Neurosurg Psychiatry. 2011 Mar;82(3):340-3. doi:
10.1136/jnnp.2008.158428. Epub 2010 Jun 20.
Postoperative recovery of hippocampal contralateral diffusivity in medial
temporal lobe epilepsy correlates with memory functions.
Pfeuty M(1), Thivard L, Dupont S, Adam C, Baulac M, Samson S.
Author information:
(1)Laboratoire d’Imagerie Moléculaire et Fonctionnelle, Université Bordeaux 2,
Bordeaux, France.
This study aimed at determining if the recovery of mean diffusivity (MD) in the
contralateral non sclerotic hippocampus is correlated with a change in memory
outcome after surgery in patients with medial temporal lobe epilepsy (MTLE).
Verbal and non-verbal memory scores and MD were assessed in 23 patients with
MTLE before and after surgical treatment of epilepsy. The recovery of MD in the
left hippocampus was correlated with the performance on verbal memory tests, and
the recovery of MD in all patients was correlated with the performance on
non-verbal memory tests. This finding strengthens the hypothesis that reversible
diffusion abnormalities in the contralateral hippocampus in MTLE are linked to
the active epileptic process that seems to interfere with memory abilities.
DOI: 10.1136/jnnp.2008.158428
PMID: 20562455 [Indexed for MEDLINE]