Persistence of amygdala gamma oscillations during extinction learning predicts spontaneous fear recovery.

J. Courtin, N. Karalis, C. Gonzalez-Campo, H. Wurtz, C. Herry
Neurobiology of Learning and Memory. 2014-09-01; 113: 82-89
DOI: 10.1016/j.nlm.2013.09.015

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1. Neurobiol Learn Mem. 2014 Sep;113:82-9. doi: 10.1016/j.nlm.2013.09.015. Epub 2013
Sep 30.

Persistence of amygdala gamma oscillations during extinction learning predicts
spontaneous fear recovery.

Courtin J(1), Karalis N(1), Gonzalez-Campo C(1), Wurtz H(1), Herry C(2).

Author information:
(1)INSERM, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, 33077 Bordeaux,
France; Univ. Bordeaux, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, 33077
Bordeaux, France.
(2)INSERM, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, 33077 Bordeaux,
France; Univ. Bordeaux, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, 33077
Bordeaux, France. Electronic address: .

Extinction of auditory fear conditioning induces a temporary inhibition of
conditioned fear responses that can spontaneously reappear with the passage of
time. Several lines of evidence indicate that extinction learning relies on the
recruitment of specific neuronal populations within the basolateral amygdala. In
contrast, post-extinction spontaneous fear recovery is thought to result from
deficits in the consolidation of extinction memory within prefrontal neuronal
circuits. Interestingly, recent data indicates that the strength of gamma
oscillations in the basolateral amygdala during auditory fear conditioning
correlates with retrieval of conditioned fear responses. In the present
manuscript we evaluated the hypothesis that post-extinction spontaneous fear
recovery might depend on the maintenance of gamma oscillations within the
basolateral amygdala by using single unit and local field potential recordings in
behaving mice. Our results indicate that gamma oscillations in the basolateral
amygdala were enhanced following fear conditioning, whereas during extinction
learning gamma profiles were more heterogeneous despite similar extinction
learning rates. Remarkably, variations in the strength of gamma power within the
basolateral amygdala between early and late stages of extinction linearly
predicted the level of post-extinction spontaneous fear recovery. These data
suggest that maintenance of gamma oscillations in the basolateral amygdala during
extinction learning is a strong predictive factor of long term spontaneous fear
recovery.

Copyright © 2013 Elsevier Inc. All rights reserved.

DOI: 10.1016/j.nlm.2013.09.015
PMID: 24091205 [Indexed for MEDLINE]


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