Pavlovian to instrumental transfer: A neurobehavioural perspective
Neuroscience & Biobehavioral Reviews. 2010-07-01; 34(8): 1277-1295
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1. Neurosci Biobehav Rev. 2010 Jul;34(8):1277-95. doi:
10.1016/j.neubiorev.2010.03.007. Epub 2010 Apr 10.
Pavlovian to instrumental transfer: a neurobehavioural perspective.
Holmes NM(1), Marchand AR, Coutureau E.
(1)CNRS and Université de Bordeaux, UMR 5228, Talence, France.
Pavlovian-to-instrumental transfer (PIT) is a key concept in developing our
understanding of cue-controlled behaviours. Here we have reviewed the literature
on behavioural and neurobiological factors that influence PIT. Meta-analyses of
the data for individual groups in PIT studies revealed that PIT is related to
both the order and amounts of instrumental and Pavlovian training, and that it is
critically determined by competition between instrumental and Pavlovian
responses. We directly addressed the role of response competition in PIT in two
experiments which showed that extensive Pavlovian conditioning produced more
Pavlovian magazine visits and weaker PIT than moderate Pavlovian conditioning
(Experiment 1); and that PIT lost after extensive Pavlovian conditioning was
restored by Pavlovian extinction training (Experiment 2). These findings confirm
that response competition is indeed an important determinant of PIT. This has
significant implications for lesion and inactivation studies that assess the
neurobiological substrates of PIT, as well as attempts to demonstrate PIT in the
drug self-administration paradigm where the effect is yet to be reliably shown.
PMID: 20385164 [Indexed for MEDLINE]