[Overview of acute and chronic stress responses].

Marie-Pierre Moisan, Michel Le Moal
Med Sci (Paris). 2012-06-01; 28(6-7): 612-617
DOI: 10.1051/medsci/2012286014

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1. Med Sci (Paris). 2012 Jun-Jul;28(6-7):612-7. doi: 10.1051/medsci/2012286014. Epub
2012 Jul 16.

[Overview of acute and chronic stress responses].

[Article in French]

Moisan MP(1), Le Moal M.

Author information:
(1)Institut national de la recherche agronomique, nutrition et neurobiologie
intégrée, Bordeaux, France.

The psychobiological concept of stress built up over the years since the 1930s.
The understanding of the neurobiological mechanisms involved has progressed
remarkably during the past years. This article provides an overview of the recent
data opposing acute and chronic stress. The former is an adaptative response of
the organism to cope with the fluctuations of the environment and thereby is
essential for survival. By contrast, chronic stress is deleterious and leads to
various disease states in vulnerable individuals. Its adverse effects on the
brain and the body result from a dysregulation of the stress system with various
origins and mechanisms which we will discuss in this review.

© 2012 médecine/sciences – Inserm / SRMS.

DOI: 10.1051/medsci/2012286014
PMID: 22805137 [Indexed for MEDLINE]

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