Oscillatory entrainment of subthalamic nucleus neurons and behavioural consequences in rodents and primates
European Journal of Neuroscience. 2012-07-31; 36(9): 3246-3257
DOI: 10.1111/j.1460-9568.2012.08246.x
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1. Eur J Neurosci. 2012 Nov;36(9):3246-57. doi: 10.1111/j.1460-9568.2012.08246.x.
Epub 2012 Jul 31.
Oscillatory entrainment of subthalamic nucleus neurons and behavioural
consequences in rodents and primates.
Syed EC(1), Benazzouz A, Taillade M, Baufreton J, Champeaux K, Falgairolle M,
Bioulac B, Gross CE, Boraud T.
Author information:
(1)Institut des Maladies Neurodégénératives, CNRS UMR 5293, Université Bordeaux
Segalen, Bordeaux Cedex, France.
We investigated the functional role of oscillatory activity in the local field
potential (LFP) of the subthalamic nucleus (STN) in the pathophysiology of
Parkinson’s disease (PD). It has been postulated that beta (15-30 Hz) oscillatory
activity in the basal ganglia induces PD motor symptoms. To assess this
hypothesis, an LFP showing significant power in the beta frequency range (23 Hz)
was used as a stimulus both in vitro and in vivo. We first demonstrated in rat
brain slices that STN neuronal activity was driven by the LFP stimulation. We
then applied beta stimulation to the STN of 16 rats and two monkeys while
quantifying motor behaviour. Although stimulation-induced behavioural effects
were observed, stimulation of the STN at 23 Hz induced no significant decrease in
motor performance in either rodents or primates. This study is the first to show
LFP-induced behaviour in both rats and primates, and highlights the complex
relationship between beta power and parkinsonian symptoms.
© 2012 The Authors. European Journal of Neuroscience © 2012 Federation of
European Neuroscience Societies and Blackwell Publishing Ltd.
DOI: 10.1111/j.1460-9568.2012.08246.x
PMID: 22853738 [Indexed for MEDLINE]