Organization and dynamics of AMPA receptors inside synapses-nano-organization of AMPA receptors and main synaptic scaffolding proteins revealed by super-resolution imaging.
Current Opinion in Chemical Biology. 2014-06-01; 20: 120-126
DOI: 10.1016/j.cbpa.2014.05.017
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1. Curr Opin Chem Biol. 2014 Jun;20:120-6. doi: 10.1016/j.cbpa.2014.05.017. Epub
2014 Jun 27.
Organization and dynamics of AMPA receptors inside synapses-nano-organization of
AMPA receptors and main synaptic scaffolding proteins revealed by
super-resolution imaging.
Hosy E(1), Butler C(2), Sibarita JB(3).
Author information:
(1)University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR
5297, F-33000 Bordeaux, France; CNRS, UMR 5297, F-33000 Bordeaux, France.
(2)University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR
5297, F-33000 Bordeaux, France; CNRS, UMR 5297, F-33000 Bordeaux, France; Imagine
Optic, 18 rue Charles de Gaulle, 91400 Orsay, France.
(3)University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR
5297, F-33000 Bordeaux, France; CNRS, UMR 5297, F-33000 Bordeaux, France.
Electronic address: .
Progresses in microscopy have often led to major discoveries in neuroscience, and
the recent advent of super-resolution microscopy is no exception. In this review,
we will show how imaging has advanced our modern vision of synaptic function.
More particularly, we will emphasize how novel nanoscopy techniques have helped
in deciphering the organization of post-synaptic proteins, offering new insight
into the mechanism of synaptic transmission.
Copyright © 2014 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.cbpa.2014.05.017
PMID: 24975376 [Indexed for MEDLINE]