[Epub ahead of print]

Objective Level of Alertness and Inhibitory Control Predict Highway Driving Impairment in Adults With ADHD.

Stéphanie Bioulac, Patricia Sagaspe, Jean-Arthur Micoulaud-Franchi, Ellemarije Altena, Jacques Taillard, Carmen Schröder, Manuel-Pierre Bouvard, Colette Fabrigoule, Pierre Philip
J Atten Disord. 2016-03-23; : 108705471663375
DOI: 10.1177/1087054716633751

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Objective Level of Alertness and Inhibitory Control Predict Highway Driving
Impairment in Adults With ADHD.

Bioulac S(1), Sagaspe P(2), Micoulaud-Franchi JA(2), Altena E(3), Taillard J(2),
Schröder C(4), Bouvard MP(5), Fabrigoule C(3), Philip P(2).

Author information:
(1)Pôle Universitaire Psychiatrie Enfants et Adolescents, Bordeaux, France
Université de Bordeaux, France Unité de Service et de Recherche du Centre
National de la Recherche Scientifique 3413 (USR CNRS 3413), Sommeil, Attention et
Neuropsychiatrie (SANPSY), Bordeaux, France .
(2)Université de Bordeaux, France Unité de Service et de Recherche du Centre
National de la Recherche Scientifique 3413 (USR CNRS 3413), Sommeil, Attention et
Neuropsychiatrie (SANPSY), Bordeaux, France Centre Hospitalier Universitaire
(CHU) Pellegrin, Clinique du Sommeil, Bordeaux, France.
(3)Université de Bordeaux, France Unité de Service et de Recherche du Centre
National de la Recherche Scientifique 3413 (USR CNRS 3413), Sommeil, Attention et
Neuropsychiatrie (SANPSY), Bordeaux, France.
(4)University of Strasbourg, France Institute for Cellular and Integrative
Neuroscience, Strasbourg, France.
(5)Pôle Universitaire Psychiatrie Enfants et Adolescents, Bordeaux, France.

OBJECTIVE: It remains unclear whether daytime impairments in ADHD patients are
better explained by an altered level of alertness and/or by cognitive deficits.
The aim of this study was to determine the respective contribution of these
factors on driving performance in ADHD adults.
METHOD: ADHD adults (n= 39) and healthy controls (n= 18) underwent a nocturnal
polysomnography (PSG) followed by a Maintenance of Wakefulness Test (MWT), a
simulated driving task, and a neuropsychological evaluation.
RESULTS: ADHD patients had shorter mean sleep latency on the MWT and worse
driving performance than controls. They also made more errors on attention and
executive functioning tests. Logistic regression analyses showed that inhibition
deficits and objective daytime sleepiness predicted highway driving performance
in ADHD.
CONCLUSION: Our study shows that not only inhibitory control deficits but also
pathological level of alertness independently contribute to highway driving
impairment in ADHD patients, providing a better understanding of the
pathophysiological mechanisms involved in ADHD.

© The Author(s) 2016.

DOI: 10.1177/1087054716633751
PMID: 27009924


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