Nocturnal activity of 11β-hydroxy steroid dehydrogenase type 1 is increased in type 1 diabetic children.
Diabetes & Metabolism. 2013-04-01; 39(2): 163-168
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1. Diabetes Metab. 2013 Apr;39(2):163-8. doi: 10.1016/j.diabet.2012.10.001. Epub
2012 Nov 16.
Nocturnal activity of 11β-hydroxy steroid dehydrogenase type 1 is increased in
type 1 diabetic children.
Barat P(1), Brossaud J, Lacoste A, Vautier V, Nacka F, Moisan MP, Corcuff JB.
(1)Service d’endocrinologie pédiatrique, CHU de Bordeaux, hôpital des Enfants,
33000 Bordeaux, France.
AIM: The objective of this study was to investigate low-grade inflammation in
children with type 1 diabetes (T1D) and its association with cortisol levels as
well as its bioavailability through 11β-hydroxy steroid dehydrogenase type 1
METHODS: Children with T1D (n=45) and their non-diabetic siblings (n=28)
participated in the study. Interleukin-6 (IL-6) and high-sensitivity C-reactive
protein (CRPhs) were measured between 1400 and 1800h. Glucocorticoid metabolites
were measured in the first morning urine on clinic day and 11β-HSD1 activity was
estimated by tetrahydrocortisol/tetrahydrocortisone (THF/THE) ratio.
RESULTS: Diabetic patients presented with an increased THF/THE ratio compared
with controls (median: 0.68 [range: 0.45-1.18] vs 0.45 [0.27-0.98], respectively;