Nicotine dependence is associated with depression and childhood trauma in smokers with schizophrenia: results from the FACE-SZ dataset.
Eur Arch Psychiatry Clin Neurosci. 2017-04-07; 267(6): 567-577
DOI: 10.1007/s00406-017-0779-9
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1. Eur Arch Psychiatry Clin Neurosci. 2017 Sep;267(6):567-577. doi:
10.1007/s00406-017-0779-9. Epub 2017 Apr 7.
Nicotine dependence is associated with depression and childhood trauma in
smokers with schizophrenia: results from the FACE-SZ dataset.
Rey R(1)(2), D’Amato T(3)(4), Boyer L(3)(5), Brunel L(3)(6), Aouizerate B(3)(7),
Berna F(3)(8), Capdevielle D(3)(9), Chereau I(3)(10), Chesnoy-Servanin G(3)(4),
Denizot H(3)(10), Dorey JM(3)(4), Dubertret C(3)(11), Dubreucq J(3)(12), Faget
C(3)(13), Gabayet F(3)(12), Lancon C(3)(13), Mallet J(3)(11), Misdrahi D(3)(14),
Passerieux C(3)(15), Schandrin A(3)(9), Schürhoff F(3)(6), Urbach M(3)(15),
Vidailhet P(3)(8), Llorca PM(3)(10), Fond G(3)(16); FACE-SZ (FondaMental
Academic Centers of Expertise for Schizophrenia) group.
Collaborators: Andrianarisoa M, Andrianarisoa M, Aouizerate B, Berna F, Blanc O,
Brunel L, Bulzacka E, Capdevielle D, Chereau-Boudet I, Chesnoy-Servanin G,
Danion JM, D’Amato T, Deloge A, Delorme C, Denizot H, Dorey JM, Dubertret C,
Dubreucq J, Faget C, Fluttaz C, Fond G, Fonteneau S, Gabayet F, Giraud-Baro E,
Hardy-Bayle MC, Lacelle D, Lançon C, Laouamri H, Leboyer M, Le Gloahec T, Le
Strat Y, Llorca PM, Mallet J, Metairie E, Misdrahi D, Offerlin-Meyer I,
Passerieux C, Peri P, Pires S, Portalier C, Rey R, Roman C, Sebilleau M,
Schandrin A, Schürhoff F, Tessier A, Tronche AM, Urbach M, Vaillant F, Vehier A,
Vidailhet P, Vilain J, Vilà E, Yazbek H, Zinetti-Bertschy A.
Author information:
(1)Fondation FondaMental, Créteil, France. .
(2)INSERM U1028, CNRS UMR5292, Université Claude Bernard Lyon 1, Centre de
Recherche en Neurosciences de Lyon, Equipe PSYR2, Centre Hospitalier Le
Vinatier, Pole Est, 95 bd Pinel, BP 30039, 69678 Bron Cedex, France.
.
(3)Fondation FondaMental, Créteil, France.
(4)INSERM U1028, CNRS UMR5292, Université Claude Bernard Lyon 1, Centre de
Recherche en Neurosciences de Lyon, Equipe PSYR2, Centre Hospitalier Le
Vinatier, Pole Est, 95 bd Pinel, BP 30039, 69678 Bron Cedex, France.
(5)Pôle Psychiatrie Universitaire, CHU Sainte-Marguerite, F-13274, Marseille
cedex 09, France.
(6)INSERM U955, équipe de psychiatrie translationnelle, Créteil, France,
Université Paris-Est Créteil, DHU Pe-PSY, Pôle de Psychiatrie des Hôpitaux
Universitaires H Mondor, 40 rue de Mesly, F-94010, Créteil, France.
(7)Centre Hospitalier Charles Perrens, F-33076 Bordeaux, France, Université de
Bordeaux, Inserm, Neurocentre Magendie, Physiopathologie de la Plasticité
Neuronale, U862, F-33000, Bordeaux, France.
(8)Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, INSERM
U1114, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg,
France.
(9)Service Universitaire de Psychiatrie Adulte, Hôpital la Colombière, CHRU
Montpellier, Université Montpellier 1, Inserm 1061, Montpellier, France.
(10)CMP B, CHU, EA 7280 Faculté de Médecine, Université d’Auvergne, BP 69 63003,
Clermont-Ferrand Cedex 1, France.
(11)AP-HP, Department of Psychiatry, Louis Mourier Hospital, Colombes, Inserm
U894, Université Paris Diderot, Sorbonne Paris Cité, Faculté de médecine,
France.
(12)Centre Référent de Réhabilitation Psychosociale, CH Alpes Isère, Grenoble,
France.
(13)Assistance Publique des Hôpitaux de Marseille (AP-HM), pôle universitaire de
psychiatrie, Marseille, France.
(14)Centre Hospitalier Charles Perrens, F-33076 Bordeaux, France, Université de
Bordeaux, CNRS UMR 5287-INCIA, Bordeaux, France.
(15)Service de psychiatrie d’adulte, Centre Hospitalier de Versailles, UFR des
Sciences de la Santé Simone Veil, Université Versailles Saint-Quentin en
Yvelines, Versailles, France.
(16)Clinique Jeanne D’Arc-Hôpital Privé Parisien, Saint Mandé, F94000, France,
CHU Carémeau, Nîmes, F30000, France.
In a perspective of personalized care for smoking cessation, a better clinical
characterization of smokers with schizophrenia (SZ) is needed. The objective of
this study was to determine the clinical characteristics of SZ smokers with
severe nicotine (NIC) dependence. 240 stabilized community-dwelling SZ smokers
(mean age = 31.9 years, 80.4% male gender) were consecutively included in the
network of the FondaMental Expert Centers for Schizophrenia and assessed with
validated scales. Severe NIC dependence was defined by a Fagerstrom
questionnaire score ≥ 7. Depression was defined by a Calgary score ≥ 6.
Childhood trauma was self-reported by the Childhood Trauma Questionnaire score
(CTQ). Ongoing psychotropic treatment was recorded. Severe NIC dependence was
identified in 83 subjects (34.6%), depression in 60 (26.3%). 44 (22.3%) subjects
were treated by antidepressants. In a multivariate model, severe NIC dependence
remained associated with depression (OR = 3.2, p = 0.006), male gender
(OR = 4.5, p = 0.009) and more slightly with childhood trauma (OR = 1.03,
p = 0.044), independently of socio-demographic characteristics, psychotic
symptoms severity, psychotropic treatments and alcohol disorder. NIC dependence
was independently and strongly associated with, respectively, depression and
male gender in schizophrenia, and only slightly with history of childhood
trauma. Based on these results, the care of both nicotine dependence and
depression should be evaluated for an effective smoking cessation intervention
in schizophrenia.
DOI: 10.1007/s00406-017-0779-9
PMID: 28389889 [Indexed for MEDLINE]