Neuronal activity correlated with checking behaviour in the subthalamic nucleus of patients with obsessive-compulsive disorder.

Pierre Burbaud, Anne-Hélène Clair, Nicolas Langbour, Sara Fernandez-Vidal, Michel Goillandeau, Thomas Michelet, Eric Bardinet, Isabelle Chéreau, Franck Durif, Mircea Polosan, Stephan Chabardès, Denys Fontaine, Marie-Noelle Magnié-Mauro, Jean-Luc Houeto, Benoît Bataille, Bruno Millet, Marc Vérin, Nicolas Baup, Marie-Odile Krebs, Philippe Cornu, Antoine Pelissolo, Christophe Arbus, Marion Simonetta-Moreau, Jérôme Yelnik, Marie-Laure Welter, Luc Mallet,
Brain. 2013-01-01; 136(1): 304-317
DOI: 10.1093/brain/aws306

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1. Brain. 2013 Jan;136(Pt 1):304-17. doi: 10.1093/brain/aws306.

Neuronal activity correlated with checking behaviour in the subthalamic nucleus
of patients with obsessive-compulsive disorder.

Burbaud P(1), Clair AH, Langbour N, Fernandez-Vidal S, Goillandeau M, Michelet T,
Bardinet E, Chéreau I, Durif F, Polosan M, Chabardès S, Fontaine D, Magnié-Mauro
MN, Houeto JL, Bataille B, Millet B, Vérin M, Baup N, Krebs MO, Cornu P,
Pelissolo A, Arbus C, Simonetta-Moreau M, Yelnik J, Welter ML, Mallet L; French
Stimulation dans le Trouble Obsessionnel Compulsif Study Group.

Collaborators: Mallet L, Agid Y, Aouizerate B, Arbus C, Bougerol T, Damier P,
Fontaine D, Houeto JL, Krebs MO, Lemaire JJ, Mallet L, Millet B, Pollak P,
Hourton D, Aprelon S, Jourdain C, Bardinet E, Yelnik J, Burbaud P, Welter ML,
Clair AH, Czernecki V, Vérin M, du Montcel S, Madar D, Burbaud P, Clair AH,
Mallet L, Welter ML, Yelnik J, Mallet L, Pelissolo A, Agid Y, Cornu P, Navarro S,
Welter ML, Hartmann A, Pidoux B, Grabli D, Czernecki V, Dormont D, Galanaud D,
Yelnik J, Bardinet E, Béhar C, Worbe Y, Clair AH, Moutaud B, Aouizerate B,
Burbaud P, Cuny E, Guehl D, Rotgé JY, Bioulac B, Llorca PM, Chéreau I, Lemaire
JJ, Durif F, Derost P, Coste J, Gabrillargues J, Barget M, de Chazeron I,
Bougerol T, Polosan M, Benabid AL, Chabardès S, Seigneuret E, Krack P, Pollak P,
Ardouin C, Piallat B, Bas JF, Damier P, Lajat Y, Raoul S, Mattei V, Fontaine D,
Borg M, Paquis P, Michel E, Robert P, Magnié-Moro MN, Papetti F, Baup N, Devaux
B, Krebs MO, Oppenheimer C, Olié JP, Ranoux D, Chayet M, Houeto JL, Jaafari N,
Bataille B, Mesnage V, Besnard S, Gil R, Audouin V, Senon JL, Millet B, Vérin M,
Drapier D, Sauleau P, Drapier S, Arbus C, Lazorthe Y, Chaynes P, Fabre N,
Simonetta M, Schmitt L, Lotterie JA, Camassel C, Best N, Aussilloux JC, Blond S,
Feingold J, Sicard D, Adès J, Cottraux J, Goudemand M.

Author information:
(1)Institut des Maladies Neurodégénératives, CNRS UMR5293, Université Victor
Segalen, 146, rue Léo Saignat, 33076 Bordeaux, France.

Doubt, and its behavioural correlate, checking, is a normal phenomenon of human
cognition that is dramatically exacerbated in obsessive-compulsive disorder. We
recently showed that deep brain stimulation in the associative-limbic area of the
subthalamic nucleus, a central core of the basal ganglia, improved
obsessive-compulsive disorder. To understand the physiological bases of symptoms
in such patients, we recorded the activity of individual neurons in the
therapeutic target during surgery while subjects performed a cognitive task that
gave them the possibility of unrestricted repetitive checking after they had made
a choice. We postulated that the activity of neurons in this region could be
influenced by doubt and checking behaviour. Among the 63/87 task-related neurons
recorded in 10 patients, 60% responded to various combinations of instructions,
delay, movement or feedback, thus highlighting their role in the integration of
different types of information. In addition, task-related activity directed
towards decision-making increased during trials with checking in comparison with
those without checking. These results suggest that the associative-limbic
subthalamic nucleus plays a role in doubt-related repetitive thoughts. Overall,
our results not only provide new insight into the role of the subthalamic nucleus
in human cognition but also support the fact that subthalamic nucleus modulation
by deep brain stimulation reduced compulsive behaviour in patients with
obsessive-compulsive disorder.

DOI: 10.1093/brain/aws306
PMID: 23365104 [Indexed for MEDLINE]

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