Neuroimaging correlates of subjective memory deficits in a community population
Neurology. 2008-04-28; 70(18): 1601-1607
DOI: 10.1212/01.wnl.0000310982.99438.54
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1. Neurology. 2008 Apr 29;70(18):1601-7. doi: 10.1212/01.wnl.0000310982.99438.54.
Neuroimaging correlates of subjective memory deficits in a community population.
Stewart R(1), Dufouil C, Godin O, Ritchie K, Maillard P, Delcroix N, Crivello F,
Mazoyer B, Tzourio C.
Author information:
(1)King’s College London, Institute of Psychiatry, London, UK.
BACKGROUND: Subjective memory deficit (SMD) is one of few potential presenting
symptoms for people with early cognitive impairment. However, associations with
underlying brain changes are unclear.
METHODS: In a community sample of 1,779 people without dementia, and with
neuroimaging (MRI) data, associations were investigated for SMD with white matter
lesion volume and with the following volumetric measures: gray and white matter,
CSF, hippocampal, parahippocampal, and amygdalar. Covariates included depressive
symptoms (Center for Epidemiologic Studies Depression Scale), a battery of
cognitive tests, physical health, and social activity.
RESULTS: SMD was present in 26.4% of the sample. Of the neuroimaging measures
analyzed, SMD was most strongly associated with temporal WML (OR for highest
quintile compared to the remainder 1.44, 95% CI 1.12-1.85), and lower hippocampal
volume (OR per decreasing quintile 1.22, 1.11-1.35). These associations were
independent of all other covariates, including cognitive function.
CONCLUSIONS: Subjective memory deficit (SMD) was associated with neuroimaging
characteristics in the temporal and hippocampal regions, suggesting that SMD may,
at least in some cases, represent a realistic appraisal of underlying brain
function independent of measured cognition. However, further research is required
for volumetric measures and SMD to establish whether the association reflects
lifelong structure or neurodegenerative changes.
DOI: 10.1212/01.wnl.0000310982.99438.54
PMID: 18443310 [Indexed for MEDLINE]