Neuroanatomical divergence between two substrains of C57BL/6J inbred mice entails differential radial-maze learning
L. Jamot, J.-Y. Bertholet, W.E. Crusio
Brain Research. 1994-05-01; 644(2): 352-356
DOI: 10.1016/0006-8993(94)91703-5
Brain Research. 1994-05-01; 644(2): 352-356
DOI: 10.1016/0006-8993(94)91703-5
Compared to the parental strain C57BL/6J, male mice from the mutated substrain C57BL/6JNmg show smaller hippocampal intra- and infrapyramidal mossy fiber projections and a correlated inability to master a simple spatial radial-maze task. Possibly, these two substrains differ for only one single gene, making them a valuable model to investigate the physiological pathways leading from genotype to neurobehavioral phenotype.