Neural correlates of three types of negative life events during angry face processing in adolescents.

Fanny Gollier-Briant, Marie-Laure Paillère-Martinot, Hervé Lemaitre, Ruben Miranda, Hélène Vulser, Robert Goodman, Jani Penttilä, Maren Struve, Tahmine Fadai, Viola Kappel, Luise Poustka, Yvonne Grimmer, Uli Bromberg, Patricia Conrod, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Christian Büchel, Herta Flor, Juergen Gallinat, Hugh Garavan, Andreas Heinz, Claire Lawrence, Karl Mann, Frauke Nees, Tomas Paus, Zdenka Pausova, Vincent Frouin, Marcella Rietschel, Trevor W. Robbins, Michael N. Smolka, Gunter Schumann, Jean-Luc Martinot, Eric Artiges,
Social Cognitive and Affective Neuroscience. 2016-10-03; 11(12): 1961-1969
DOI: 10.1093/scan/nsw100

PubMed
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Gollier-Briant F(1), Paillère-Martinot ML(1)(2), Lemaitre H(1), Miranda R(1),
Vulser H(1), Goodman R(3), Penttilä J(4), Struve M(5), Fadai T(6), Kappel V(7),
Poustka L(8), Grimmer Y(5), Bromberg U(6), Conrod P(9), Banaschewski T(8), Barker
GJ(3), Bokde AL(10), Büchel C(7), Flor H(5), Gallinat J(11), Garavan H(10)(12),
Heinz A(11), Lawrence C(13), Mann K(5), Nees F(5)(8), Paus T(14), Pausova Z(15),
Frouin V(16), Rietschel M(5), Robbins TW(17), Smolka MN(18), Schumann G(3)(19);
IMAGEN Consortium+, Martinot JL(20)(21), Artiges E(1)(22).

Author information:
(1)INSERM, UMR 1000, Research Unit NeuroImaging and Psychiatry, Service
Hospitalier Frédéric Joliot, Orsay, University Paris-Sud, University Paris
Saclay, Orsay, and Maison De Solenn, University Paris Descartes, Paris, France.
(2)AP-HP, Department of Adolescent Psychopathology and Medicine, Maison De
Solenn, Cochin Hospital, Paris, France.
(3)King’s College London Institute of Psychiatry, Psychology & Neuroscience,
London, United Kingdom.
(4)University of Tampere, Medical School, Tampere, Finland.
(5)Department of Cognitive and Clinical Neuroscience, Central Institute of Mental
Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
(6)Universitaetsklinikum Hamburg Eppendorf, Hamburg, Germany.
(7)Department of Child and Adolescent Psychiatry, Psychosomatics and
Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
(8)Department of Child and Adolescent Psychiatry and Psychotherapy, Central
Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University,
Mannheim, Germany.
(9)CHU Ste Justine, Department of Psychiatry, Université De Montréal, Montréal,
QC, Canada.
(10)Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
(11)Department of Psychiatry and Psychotherapy, Campus CharitéMitte, Charité –
Universitätsmedizin, Berlin, Germany.
(12)Departments of Psychiatry and Psychology, University of Vermont, Burlington,
VT, USA.
(13)School of Psychology, University of Nottingham, Nottingham, United Kingdom.
(14)Rotman Research Institute.
(15)Department of Physiology and Nutritional Sciences, the Hospital for Sick
Children, University of Toronto, Toronto, Canada.
(16)Neurospin, Commissariat à L’Energie Atomique Et Aux Energies Alternatives,
Saclay, France.
(17)Psychology and Behavioural and Clinical neuroscience Institute, University of
Cambridge, Cambridge, United Kingdom.
(18)Department of Psychiatry and Neuroimaging Center, Technische
Universit㲠Dresden, Germany.
(19)MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, London,
United Kingdom.
(20)INSERM, UMR 1000, Research Unit NeuroImaging and Psychiatry, Service
Hospitalier Frédéric Joliot, Orsay, University Paris-Sud, University Paris
Saclay, Orsay, and Maison De Solenn, University Paris Descartes, Paris, France
.
(21)CENIR Centre de Neuroimagerie de Recherche at Institute of Brain and Spine,
Pitié – Salpétrière, Paris, France.
(22)Psychiatry Department, Orsay Hospital, Orsay, France.

Negative life events (NLE) contribute to anxiety and depression disorders, but
their relationship with brain functioning in adolescence has rarely been studied.
We hypothesized that neural response to social threat would relate to NLE in the
frontal-limbic emotional regions. Participants (N = 685) were drawn from the
Imagen database of 14-year-old community adolescents recruited in schools. They
underwent functional MRI while viewing angry and neutral faces, as a probe to
neural response to social threat. Lifetime NLEs were assessed using the
‘distress’, ‘family’ and ‘accident’ subscales from a life event dimensional
questionnaire. Relationships between NLE subscale scores and neural response were
investigated. Links of NLE subscales scores with anxiety or depression outcomes
at the age of 16 years were also investigated. Lifetime ‘distress’ positively
correlated with ventral-lateral orbitofrontal and temporal cortex activations
during angry face processing. ‘Distress’ scores correlated with the probabilities
of meeting criteria for Generalized Anxiety Disorder or Major Depressive Disorder
at the age of 16 years. Lifetime ‘family’ and ‘accident’ scores did not relate
with neural response or follow-up conditions, however. Thus, different types of
NLEs differentially predicted neural responses to threat during adolescence, and
differentially predicted a de novo internalizing condition 2 years later. The
deleterious effect of self-referential NLEs is suggested.

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