Nanoembossing of thermoplastic polymers for microfluidic applications
Appl. Phys. Lett.. 2002-05-13; 80(19): 3614-3616
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1. Hosp Pediatr. 2012 Oct;2(4):235-42.
La Crosse viral infection in hospitalized pediatric patients in Western North
Miller A(1), Carchman R, Long R, Denslow SA.
(1)Department of Pediatrics, Mission Hospital, Asheville, North Carolina 28801,
OBJECTIVE: La Crosse infection, caused by a rare mosquito-transmitted virus, is
endemic in Western North Carolina. Given the large number of cases at our
institution, our goal was to describe the presentation, management, and clinical
course for pediatric patients with this disease.
METHODS: We retrospectively reviewed medical records from pediatric patients with
antibody-confirmed La Crosse infection admitted to Mission Hospital July 2004
through August 2009. Demographics, clinical characteristics, management methods,
length of hospital stay, and complications were analyzed. Regression analysis was
used to assess relationships between presentation and clinical course.
RESULTS: Forty-seven pediatric patients were identified with antibody-confirmed
La Crosse infection. Seventy percent were male, and the median age was 8 years.
Admission signs and symptoms included fever (43%), headache (94%), vomiting
(78%), altered mental status (58%), and seizures (61%). All patients had
pleocytosis on cerebrospinal fluid studies (range 10-1063 cells/mm3). Median
length of stay was 5 days. Seizure at admission was associated with an increased
length of stay (2.4 additional days, 95% confidence interval 0.7-4.1). Eighteen
patients (38%) received intensive care, 7 (19%) received parenteral or enteral
(via nasogastric tube) nutrition, and 4 (9%) received mechanical ventilation. No
statistically significant associations between presenting signs and symptoms and
complications were found. Treatments included antibiotics (87%), antiviral
medication (55%), seizure prophylaxis (47%), and isotonic fluids (98%).
CONCLUSIONS: Our data reflect few indicators to predict clinical course during
hospital stay. Management strategies should include attention to development of
seizure activity and preventive measures for syndrome of inappropriate
PMID: 24313031 [Indexed for MEDLINE]