Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequency activity
Nat Commun. 2016-05-10; 7(1):
DOI: 10.1038/ncomms11298
Read on PubMed
1. Nat Commun. 2016 May 10;7:11298. doi: 10.1038/ncomms11298.
Myelinating satellite oligodendrocytes are integrated in a glial syncytium
constraining neuronal high-frequency activity.
Battefeld A(1), Klooster J(1), Kole MH(1)(2).
Author information:
(1)Axonal Signalling Group, Netherlands Institute for Neuroscience, Royal Academy
of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands.
(2)Cell Biology, Department of Biology, Faculty of Science, University of
Utrecht, 3584 CH Utrecht, The Netherlands.
Satellite oligodendrocytes (s-OLs) are closely apposed to the soma of neocortical
layer 5 pyramidal neurons but their properties and functional roles remain
unresolved. Here we show that s-OLs form compact myelin and action potentials of
the host neuron evoke precisely timed Ba(2+)-sensitive K(+) inward rectifying
(Kir) currents in the s-OL. Unexpectedly, the glial K(+) inward current does not
require oligodendrocytic Kir4.1. Action potential-evoked Kir currents are in part
mediated by gap-junction coupling with neighbouring OLs and astrocytes that form
a syncytium around the pyramidal cell body. Computational modelling predicts that
glial Kir constrains the perisomatic [K(+)]o increase most importantly during
high-frequency action potentials. Consistent with these predictions neurons with
s-OLs showed a reduced probability for action potential burst firing during
[K(+)]o elevations. These data suggest that s-OLs are integrated into a glial
syncytium for the millisecond rapid K(+) uptake limiting activity-dependent
[K(+)]o increase in the perisomatic neuron domain.
DOI: 10.1038/ncomms11298
PMCID: PMC4866043
PMID: 27161034 [Indexed for MEDLINE]