Multinodular and Vacuolating Posterior Fossa Lesions of Unknown Significance.

A. Lecler, J. Bailleux, B. Carsin, H. Adle-Biassette, S. Baloglu, C. Bogey, F. Bonneville, E. Calvier, P.-O. Comby, J.-P. Cottier, F. Cotton, R. Deschamps, C. Diard-Detoeuf, F. Ducray, L. Duron, C. Drissi, M. Elmaleh, J. Farras, J.A. Garcia, E. Gerardin, S. Grand, D.C. Jianu, S. Kremer, N. Magne, M. Mejdoubi, A. Moulignier, M. Ollivier, S. Nagi, M. Rodallec, J.-C. Sadik, N. Shor, T. Tourdias, C. Vandendries, V. Broquet, J. Savatovsky,
AJNR Am J Neuroradiol. 2019-09-26; :
DOI: 10.3174/ajnr.a6223

PubMed
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Lecler A(1), Bailleux J(2), Carsin B(3), Adle-Biassette H(4), Baloglu S(5), Bogey
C(6), Bonneville F(7), Calvier E(8), Comby PO(9), Cottier JP(10)(11), Cotton
F(12)(13), Deschamps R(14), Diard-Detoeuf C(15), Ducray F(16)(17)(18), Duron
L(2), Drissi C(19), Elmaleh M(20), Farras J(21), Garcia JA(8), Gerardin E(22),
Grand S(23), Jianu DC(24), Kremer S(5), Magne N(22), Mejdoubi M(25), Moulignier
A(14), Ollivier M(26), Nagi S(19)(27), Rodallec M(28), Sadik JC(2), Shor N(29),
Tourdias T(30), Vandendries C(2)(31), Broquet V(32), Savatovsky J(2)(3)(33);
ENIGMA Investigation Group (EuropeaN Interdisciplinary Group for MVNT Analysis).

Author information:
(1)From the Departments of Neuroradiology (A.L., J.B., L.D., J.-C.S., C.V., V.B.,
J.S.) .
(2)From the Departments of Neuroradiology (A.L., J.B., L.D., J.-C.S., C.V., V.B.,
J.S.).
(3)Department of Radiology (B.C., J.S.), Centre Hospitalier Régional
Universitaire de Rennes, Rennes, France.
(4)Department of Pathology (H.A.-B.), Lariboisière Hospital, Paris Diderot,
Paris-Cité-Sorbonne University, Paris, France.
(5)Department of Radiology (S.B., S.K.), University Hospital of Strasbourg,
Strasbourg, France.
(6)Department of Neuroradiology (C.B.), Centre Hospitalier Universitaire Limoges,
Limoges, France.
(7)Department of Neuroradiology (F.B.), Hôpital Pierre-Paul-Riquet, Centre
Hospitalier Universitaire Purpan, Toulouse, France.
(8)Neurology Department (E.C., J.A.G.), Hôpital René et Guillaume-Laënnec, Centre
Hospitalier Universitaire de Nantes, Saint-Herblain, France.
(9)Department of Vascular and Interventional Radiology (P.-O.C.), Image-Guided
Therapy Center, François-Mitterrand University Hospital, Dijon Cedex, France.
(10)Department of Radiology (J.-P.C.), Centre Hospitalier Régional Universitaire
de Tours, Tours, France.
(11)Brain and Imaging Laboratory (J.-P.C.), UMR U930, National Institute for
Health and Medical Research, François-Rabelais University, Tours, France.
(12)Service de Radiologie (F.C.), Centre Hospitalier Lyon-Sud, Hospices Civils de
Lyon, University Claude Bernard Lyon 1, Lyon, France.
(13)Centre de Recherche en Acquisition et Traitement de l’Image pour la Santé
(CREATIS) (F.C.), National Institute for Health and Medical Research U1044/Centre
National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 5220,
Lyon, France.
(14)Neurology (R.D., A.M.), Fondation Ophtalmologique A. Rothschild, Paris,
France.
(15)Department of Neurology (C.D.-D.), CH Sainte-Périne, Paris, France.
(16)Department of Neuro-Oncology (F.D.), Lyon French Reference Center of
Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Hôpital
Neurologique, Bron Cedex, France.
(17)Synatac Team (F.D.), NeuroMyoGene Institut, National Institute for Health and
Medical Research U1217/Centre National de la Recherche Scientifique (CNRS) Unité
Mixte de Recherche (UMR) 5310, Lyon, France.
(18)University Claude Bernard Lyon 1 (F.D.), Lyon, France.
(19)Institut National de Neurologie (C.D., S.N.), Service de Neuroradiologie,
Université de Tunis El Manar, Faculté de Médecine de Tunis, Tunis, Tunisia.
(20)Pediatric Radiology Department (M.E.), Robert Debré Hospital, Paris, France.
(21)Jordi Radiologia C/de la Roda (J.F.), Andorra la Vella, Andorra.
(22)Department of Neuroradiology and MRI (E.G., N.M.), Rouen University Hospital,
Rouen, France.
(23)Neuroradiologie Diagnostique et Interventionnelle et IRM Nord (S.G.), Centre
Hospitalier et Universitaire de Alpes Grenoble, Grenoble, France.
(24)Department of Neurology (D.C.J.), Victor Babes University of Medicine and
Pharmacy, Timisoara, Romania.
(25)Department of Neuroradiology (M.M.), University Hospital of Martinique,
Fort-de-France, Martinique, France.
(26)Groupe Hospitalier Pellegrin (M.O.), Bordeaux, France.
(27)Clinique les Berges du Lac (S.N.), les Berges du Lac, Tunis, Tunisia.
(28)Centre d’Imagerie Centre Cardiologique du Nord (M.R.), CCN, Saint-Denis,
France.
(29)Department of Neuroradiology (N.S.), Pitié-Salpêtrière Hospital, Paris,
France.
(30)Service de Neuroimagerie Diagnostique et Thérapeutique (T.T.), Centre
Hospitalier Universitaire de Bordeaux et National Institute for Health and
Medical Research U1215, Université de Bordeaux, Bordeaux, France.
(31)Centre d’Imagerie Médicale Paris 15ème (C.V.), RMX, Paris, France.
(32)Department of Neuroradiology (V.B.), Centre Hospitalier Universitaire Lille,
Lille, France.
(33)Imagerie Paris 13 (J.S.), Paris, France.

Multinodular and vacuolating neuronal tumor of the cerebrum is a rare
supratentorial brain tumor described for the first time in 2013. Here, we report
11 cases of infratentorial lesions showing similar striking imaging features
consisting of a cluster of low T1-weighted imaging and high T2-FLAIR signal
intensity nodules, which we referred to as multinodular and vacuolating posterior
fossa lesions of unknown significance. No relationship was found between the
location of the lesion and clinical symptoms. A T2-FLAIR hypointense central dot
sign was present in images of 9/11 (82%) patients. Cortical involvement was
present in 2/11 (18%) of patients. Only 1 nodule of 1 multinodular and
vacuolating posterior fossa lesion of unknown significance showed enhancement on
postcontrast T1WI. DWI, SWI, MRS, and PWI showed no malignant pattern. Lesions
did not change in size or signal during a median follow-up of 3 years, suggesting
that multinodular and vacuolating posterior fossa lesions of unknown significance
are benign malformative lesions that do not require surgical intervention or
removal.

© 2019 by American Journal of Neuroradiology.

DOI: 10.3174/ajnr.A6223
PMID: 31558497

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