MS lesions are better detected with 3D T1 gradient-echo than with 2D T1 spin-echo gadolinium-enhanced imaging at 3T.
AJNR Am J Neuroradiol. 2014-11-06; 36(3): 501-507
DOI: 10.3174/ajnr.a4152
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1. AJNR Am J Neuroradiol. 2015 Mar;36(3):501-7. doi: 10.3174/ajnr.A4152. Epub 2014
Nov 6.
MS lesions are better detected with 3D T1 gradient-echo than with 2D T1 spin-echo
gadolinium-enhanced imaging at 3T.
Crombé A(1), Saranathan M(2), Ruet A(3), Durieux M(1), de Roquefeuil E(1),
Ouallet JC(4), Brochet B(3), Dousset V(5), Tourdias T(6).
Author information:
(1)From the Service de NeuroImagerie Diagnostique et Thérapeutique (A.C., M.D.,
E.d.R., V.D., T.T.).
(2)Department of Radiology (M.S.), Stanford University, Stanford, California.
(3)Pôle de Neurosciences Cliniques (A.R., J.C.O., B.B.), Centre Hospitalier
Universitaire de Bordeaux, Bordeaux, France INSERM U862 (A.R., B.B., V.D., T.T.),
Neurocentre Magendie, Université de Bordeaux, Bordeaux, France.
(4)Pôle de Neurosciences Cliniques (A.R., J.C.O., B.B.), Centre Hospitalier
Universitaire de Bordeaux, Bordeaux, France.
(5)From the Service de NeuroImagerie Diagnostique et Thérapeutique (A.C., M.D.,
E.d.R., V.D., T.T.) INSERM U862 (A.R., B.B., V.D., T.T.), Neurocentre Magendie,
Université de Bordeaux, Bordeaux, France.
(6)From the Service de NeuroImagerie Diagnostique et Thérapeutique (A.C., M.D.,
E.d.R., V.D., T.T.) INSERM U862 (A.R., B.B., V.D., T.T.), Neurocentre Magendie,
Université de Bordeaux, Bordeaux, France. .
BACKGROUND AND PURPOSE: In multiple sclerosis, gadolinium enhancement is used to
classify lesions as active. Regarding the need for a standardized and accurate
method for detection of multiple sclerosis activity, we compared 2D-spin-echo
with 3D-gradient-echo T1WI for the detection of gadolinium-enhancing MS lesions.
MATERIALS AND METHODS: Fifty-eight patients with MS were prospectively imaged at
3T by using both 2D-spin-echo and 3D-gradient recalled-echo T1WI in random order
after the injection of gadolinium. Blinded and independent evaluation was
performed by a junior and a senior reader to count gadolinium-enhancing lesions
and to characterize their location, size, pattern of enhancement, and the
relative contrast between enhancing lesions and the adjacent white matter.
Finally, the SNR and relative contrast of gadolinium-enhancing lesions were
computed for both sequences by using simulations.
RESULTS: Significantly more gadolinium-enhancing lesions were reported on
3D-gradient recalled-echo than on 2D-spin-echo (n = 59 versus n = 30 for the
junior reader, P = .021; n = 77 versus n = 61 for the senior reader, P = .017).
The difference between the 2 readers was significant on 2D-spin-echo (P = .044),
for which images were less reproducible (κ = 0.51) than for 3D-gradient
recalled-echo (κ = 0.65). Further comparisons showed that there were
statistically more small lesions (