Mood Variability, Craving, and Substance Use Disorders: From Intrinsic Brain Network Connectivity to Daily Life Experience

Carmen Morawetz, Stella Berboth, Valentine Chirokoff, Sandra Chanraud, David Misdrahi, Fuschia Serre, Marc Auriacombe, Melina Fatseas, Joel Swendsen
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2022-11-01; :
DOI: 10.1016/j.bpsc.2022.11.002

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Morawetz C(1), Berboth S(2), Chirokoff V(3), Chanraud S(3), Misdrahi D(4), Serre F(5), Auriacombe M(6), Fatseas M(7), Swendsen J(3).

Author information:
(1)Institute of Psychology, University of Innsbruck, Innsbruck, Austria.
Electronic address: .
(2)Institute of Psychology, University of Innsbruck, Innsbruck, Austria.
(3)National Centre for Scientific Research UMR 5287 – Institut de Neurosciences
Cognitives et Intégratives d’Aquitaine, University of Bordeaux, Bordeaux,
France; École pratique des hautes études, Paris Sciences et Lettres Research
University, Paris, France.
(4)National Centre for Scientific Research UMR 5287 – Institut de Neurosciences
Cognitives et Intégratives d’Aquitaine, University of Bordeaux, Bordeaux,
France; Centre Hospitalier Charles Perrens, Bordeaux, France.
(5)Centre National de la Recherche Scientifique UMR 6033 – Sleep, Addiction and
Neuropsychiatry, University of Bordeaux, Bordeaux, France.
(6)Centre National de la Recherche Scientifique UMR 6033 – Sleep, Addiction and
Neuropsychiatry, University of Bordeaux, Bordeaux, France; Centre Hospitalier
Charles Perrens, Bordeaux, France; Centre Hospitalier Universitaire Bordeaux,
Bordeaux, France.
(7)National Centre for Scientific Research UMR 5287 – Institut de Neurosciences
Cognitives et Intégratives d’Aquitaine, University of Bordeaux, Bordeaux,
France; Centre Hospitalier Universitaire Bordeaux, Bordeaux, France.

BACKGROUND: Substance use disorders (SUDs) are major contributors to morbidity
and mortality rates worldwide, and this global burden is attributable in large
part to the chronic nature of these conditions. Increased mood variability might
represent a form of emotional dysregulation that may have particular
significance for the risk of relapse in SUD, independent of mood severity or
diagnostic status. However, the neural biomarkers that underlie mood variability
remain poorly understood.

METHODS: Ecological momentary assessment was used to assess mood variability,
craving, and substance use in real time in 54 patients treated for addiction to
alcohol, cannabis, or nicotine and 30 healthy control subjects. Such data were
jointly examined relative to spectral dynamic causal modeling of effective brain
connectivity within 4 networks involved in emotion generation and regulation.
RESULTS: Differences in effective connectivity were related to daily life
variability of emotional states experienced by persons with SUD, and mood
variability was associated with craving intensity. Relative to the control
participants, effective connectivity was decreased for patients in the
prefrontal control networks and increased in the emotion generation networks.
Findings revealed that effective connectivity within the patient group was
modulated by mood variability.

CONCLUSIONS: The intrinsic causal dynamics in large-scale neural networks
underlying emotion regulation play a predictive role in a patient’s
susceptibility to experiencing mood variability (and, subsequently, craving) in
daily life. The findings represent an important step toward informing
interventional research through biomarkers of factors that increase the risk of
relapse in persons with SUD.

Copyright © 2022 Society of Biological Psychiatry. Published by Elsevier Inc.
All rights reserved.

 

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