Molecular genetics of hypothalamic-pituitary-adrenal axis activity and function.

Pierre Mormede, Aline Foury, Pascal Barat, Jean-Benoit Corcuff, Elena Terenina, Nathalie Marissal-Arvy, Marie-Pierre Moisan
Annals of the New York Academy of Sciences. 2011-03-01; 1220(1): 127-136
DOI: 10.1111/j.1749-6632.2010.05902.x

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1. Ann N Y Acad Sci. 2011 Mar;1220:127-36. doi: 10.1111/j.1749-6632.2010.05902.x.

Molecular genetics of hypothalamic-pituitary-adrenal axis activity and function.

Mormede P(1), Foury A, Barat P, Corcuff JB, Terenina E, Marissal-Arvy N, Moisan

Author information:
(1)Université de Bordeaux, PsyNuGen, Bordeaux, France.

The hypothalamic-pituitary-adrenocortical (HPA) axis is a major neuroendocrine
system involved in the regulation of numerous physiological processes and in
adaptation to stress. A wide range of variability can be observed in all the
components of the system, and the contribution of genetic factors has been shown
in the central regulation of the axis, the production of glucocorticoid hormones
by the adrenal cortex, their bioavailability, and the efficiency of their action
at the level of receptor and postreceptor mechanisms. Numerous molecular
polymorphisms have been described that contribute to physiological variation as
well as to HPA axis-related pathological conditions. Although most studies focus
on single gene polymorphisms, future studies should aim to integrate the
different sources of variation into a systems genetic model to take into account
the strong interdependence of the different components of the axis.

© 2011 New York Academy of Sciences.

DOI: 10.1111/j.1749-6632.2010.05902.x
PMID: 21388410 [Indexed for MEDLINE]

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