Moderately delayed post-insult treatment with normobaric hyperoxia reduces excitotoxin-induced neuronal degeneration but increases ischemia-induced brain damage
Medical Gas Research. 2011-01-01; 1(1): 2
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1. Med Gas Res. 2011 Apr 27;1(1):2. doi: 10.1186/2045-9912-1-2.
Moderately delayed post-insult treatment with normobaric hyperoxia reduces
excitotoxin-induced neuronal degeneration but increases ischemia-induced brain
Haelewyn B(1), Chazalviel L, Nicole O, Lecocq M, Risso JJ, Abraini JH.
(1)ERT 1083, UMR 6232, Université de Caen Basse Normandie, CNRS, CEA, Centre
CYCERON, B,P, 5229, Boulevard Henri Becquerel, 14074 Caen cedex, France.
BACKGROUND: The use and benefits of normobaric oxygen (NBO) in patients suffering
acute ischemic stroke is still controversial.
RESULTS: Here we show for the first time to the best of our knowledge that NBO
reduces both NMDA-induced calcium influxes in vitro and NMDA-induced neuronal
degeneration in vivo, but increases oxygen and glucose deprivation-induced cell
injury in vitro and ischemia-induced brain damage produced by middle cerebral
artery occlusion in vivo.
CONCLUSIONS: Taken together, these results indicate that NBO reduces
excitotoxin-induced calcium influx and subsequent neuronal degeneration but
favors ischemia-induced brain damage and neuronal death. These findings highlight
the complexity of the mechanisms involved by the use of NBO in patients suffering
acute ischemic stroke.