Moderately delayed post-insult treatment with normobaric hyperoxia reduces excitotoxin-induced neuronal degeneration but increases ischemia-induced brain damage

Benoit Haelewyn, Laurent Chazalviel, Olivier Nicole, Myriam Lecocq, Jean-Jacques Risso, Jacques H Abraini
Medical Gas Research. 2011-01-01; 1(1): 2
DOI: 10.1186/2045-9912-1-2

PubMed
Read on PubMed



1. Med Gas Res. 2011 Apr 27;1(1):2. doi: 10.1186/2045-9912-1-2.

Moderately delayed post-insult treatment with normobaric hyperoxia reduces
excitotoxin-induced neuronal degeneration but increases ischemia-induced brain
damage.

Haelewyn B(1), Chazalviel L, Nicole O, Lecocq M, Risso JJ, Abraini JH.

Author information:
(1)ERT 1083, UMR 6232, Université de Caen Basse Normandie, CNRS, CEA, Centre
CYCERON, B,P, 5229, Boulevard Henri Becquerel, 14074 Caen cedex, France.
.

BACKGROUND: The use and benefits of normobaric oxygen (NBO) in patients suffering
acute ischemic stroke is still controversial.
RESULTS: Here we show for the first time to the best of our knowledge that NBO
reduces both NMDA-induced calcium influxes in vitro and NMDA-induced neuronal
degeneration in vivo, but increases oxygen and glucose deprivation-induced cell
injury in vitro and ischemia-induced brain damage produced by middle cerebral
artery occlusion in vivo.
CONCLUSIONS: Taken together, these results indicate that NBO reduces
excitotoxin-induced calcium influx and subsequent neuronal degeneration but
favors ischemia-induced brain damage and neuronal death. These findings highlight
the complexity of the mechanisms involved by the use of NBO in patients suffering
acute ischemic stroke.

DOI: 10.1186/2045-9912-1-2
PMCID: PMC3191484
PMID: 22146487


Know more about