Modeling nicotine addiction in rats.

Stephanie Caille, Kelly Clemens, Luis Stinus, Martine Cador
Methods in Molecular Biology. 2011-12-08; : 243-256
DOI: 10.1007/978-1-61779-458-2_15

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1. Methods Mol Biol. 2012;829:243-56. doi: 10.1007/978-1-61779-458-2_15.

Modeling nicotine addiction in rats.

Caille S(1), Clemens K, Stinus L, Cador M.

Author information:
(1)CNRS UMR 5287, “Neuropsychopharmacology of Addiction” Group, University of
Bordeaux, Bordeaux, France.

Among the human population, 15% of drug users develop a pathological drug
addiction. This figure increases substantially with nicotine, whereby more than
30% of those who try smoking develop a nicotine addiction. Drug addiction is
characterized by compulsive drug-seeking and drug-taking behaviors (craving), and
loss of control over intake despite impairment in health, social, and
occupational functions. This behavior can be accurately modeled in the rat using
an intravenous self-administration (IVSA) paradigm. Initial attempts at
establishing nicotine self-administration had been problematic, yet in recent
times increasingly reliable models of nicotine self-administration have been
developed. The present article reviews different characteristics of the nicotine
IVSA model that has been developed to examine nicotine reinforcing and
motivational properties in rats.

DOI: 10.1007/978-1-61779-458-2_15
PMID: 22231818 [Indexed for MEDLINE]

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