Matrix metalloproteinase-9 controls NMDA receptor surface diffusion through integrin β1 signaling
Journal of Neuroscience. 2009-05-06; 29(18): 6007-6012
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1. J Neurosci. 2009 May 6;29(18):6007-12. doi: 10.1523/JNEUROSCI.5346-08.2009.
Matrix metalloproteinase-9 controls NMDA receptor surface diffusion through
integrin beta1 signaling.
Michaluk P(1), Mikasova L, Groc L, Frischknecht R, Choquet D, Kaczmarek L.
(1)The Nencki Institute, 02-093 Warsaw, Poland.
Matrix metalloproteinase-9 (MMP-9) has emerged as a physiological regulator of
NMDA receptor (NMDAR)-dependent synaptic plasticity and memory. The pathways by
which MMP-9 affects NMDAR signaling remain, however, elusive. Using single
quantum dot tracking, we demonstrate that MMP-9 enzymatic activity increases
NR1-NMDAR surface trafficking but has no influence on AMPA receptor mobility. The
mechanism of MMP-9 action on NMDAR is not mediated by change in overall
extracellular matrix structure nor by direct cleavage of NMDAR subunits, but
rather through an integrin beta1-dependent pathway. These findings describe a new
target pathway for MMP-9 action in key physiological and pathological brain
PMID: 19420267 [Indexed for MEDLINE]