Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
Proc Natl Acad Sci USA. 2018-05-15; 115(22): E5154-E5163
DOI: 10.1073/pnas.1718418115
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1. Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5154-E5163. doi:
10.1073/pnas.1718418115. Epub 2018 May 15.
Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the
ENIGMA Consortium.
Kong XZ(1), Mathias SR(2), Guadalupe T(3); ENIGMA Laterality Working Group, Glahn
DC(2)(4), Franke B(5)(6), Crivello F(7), Tzourio-Mazoyer N(7), Fisher SE(3)(8),
Thompson PM(9), Francks C(1)(8).
Collaborators: Kong XZ, Mathias SR, Guadalupe T, Abé C, Agartz I, Akudjedu TN,
Aleman A, Alhusaini S, Allen NB, Ames D, Andreassen OA, Vasquez AA, Armstrong NJ,
Bergo F, Bastin ME, Batalla A, Bauer J, Baune BT, Baur-Streubel R, Biederman J,
Blaine SK, Boedhoe P, Bøen E, Bose A, Bralten J, Brandeis D, Brem S, Brodaty H,
Yüksel D, Brooks SJ, Buitelaar J, Bürger C, Bülow R, Calhoun V, Calvo A,
Canales-Rodríguez EJ, Canive JM, Cannon DM, Caparelli EC, Castellanos FX,
Cavalleri GL, Cendes F, Chaim-Avancini TM, Chantiluke K, Chen QL, Chen X, Cheng
Y, Christakou A, Clark VP, Coghill D, Connolly CG, Conzelmann A, Córdova-Palomera
A, Cousijn J, Crow T, Cubillo A, Dale A, Dannlowski U, Ambrosino de Bruttopilo S,
de Zeeuw P, Deary IJ, Delanty N, Demeter DV, Di Martino A, Dickie EW, Dietsche B,
Doan NT, Doherty CP, Doyle A, Durston S, Earl E, Ehrlich S, Ekman CJ, Elvsåshagen
T, Epstein JN, Fair DA, Faraone SV, Fernández G, Filho GB, Förster K, Fouche JP,
Foxe JJ, Frodl T, Fuentes-Claramonte P, Fullerton J, Garavan H, Garcia DDS,
Gotlib IH, Goudriaan AE, Grabe HJ, Groenewold NA, Grotegerd D, Gruber O, Gurholt
T, Haavik J, Hahn T, Hansell NK, Harris MA, Hartman CA, Hernández MDCV,
Heslenfeld D, Hester R, Hibar DP, Ho BC, Ho TC, Hoekstra PJ, van Holst RJ,
Hoogman M, Høvik MF, Howells FM, Hugdahl K, Huyser C, Ingvar M, Irwin L, Ishikawa
A, James A, Jahanshad N, Jernigan TL, Jönsson EG, Kähler C, Kaleda V, Kelly C,
Kerich M, Keshavan MS, Khadka S, Kircher T, Kohls G, Konrad K, Korucuoglu O,
Krämer B, Krug A, Kwon JS, Lambregts-Rommelse N, Landén M, Lázaro L, Lebedeva I,
Lenroot R, Lesch KP, Li Q, Lim KO, Liu J, Lochner C, London ED, Lonning V,
Lorenzetti V, Luciano M, Luijten M, Lundervold AJ, Mackey S, MacMaster FP,
Maingault S, Malpas CB, Malt UF, Mataix-Cols D, Martin-Santos R, Mayer AR,
McCarthy H, Mitchell PB, Mueller BA, Maniega SM, Mazoyer B, McDonald C, McLellan
Q, McMahon KL, McPhilemy G, Momenan R, Morales AM, Narayanaswamy JC, Moreira JCV,
Nerland S, Nestor L, Newman E, Nigg JT, Nordvik JE, Novotny S, Weiss EO, O’Gorman
RL, Oosterlaan J, Oranje B, Orr C, Overs B, Pauli P, Paulus M, Plessen KJ, von
Polier GG, Pomarol-Clotet E, Portella MJ, Qiu J, Radua J, Ramos-Quiroga JA, Reddy
YCJ, Reif A, Roberts G, Rosa P, Rubia K, Sacchet MD, Sachdev PS, Salvador R,
Schmaal L, Schulte-Rüther M, Schweren L, Seidman L, Seitz J, Serpa MH, Shaw P,
Shumskaya E, Silk TJ, Simmons AN, Simulionyte E, Sinha R, Sjoerds Z, Smelror RE,
Soliva JC, Solowij N, Souza-Duran FL, Sponheim SR, Stein DJ, Stein EA, Stevens M,
Strike LT, Sudre G, Sui J, Tamm L, Temmingh HS, Thoma RJ, Tomyshev A, Tronchin G,
Turner J, Uhlmann A, van Erp TGM, van den Heuvel OA, van der Meer D, van Eijk L,
Vance A, Veer IM, Veltman DJ, Venkatasubramanian G, Vilarroya O, Vives-Gilabert
Y, Voineskos AN, Völzke H, Vuletic D, Walitza S, Walter H, Walton E, Wardlaw JM,
Wen W, Westlye LT, Whelan CD, White T, Wiers RW, Wright MJ, Wittfeld K, Yang TT,
Yasuda CL, Yoncheva Y, Yücel M, Yun JY, Zanetti MV, Zhen Z, Zhu XX, Ziegler GC,
Zierhut K, de Zubicaray GI, Zwiers M, Glahn DC, Franke B, Crivello F,
Tzourio-Mazoyer N, Fisher SE, Thompson PM, Francks C, Farde L, Flyckt L, Engberg
G, Erhardt S, Fatouros-Bergman H, Cervenka S, Schwieler L, Piehl F, Agartz I,
Collste K, Victorsson P, Malmqvist A, Hedberg M, Orhan F.
Author information:
(1)Language and Genetics Department, Max Planck Institute for Psycholinguistics,
6525 XD Nijmegen, The Netherlands;
.
(2)Department of Psychiatry, Yale University School of Medicine, New Haven, CT
06511.
(3)Language and Genetics Department, Max Planck Institute for Psycholinguistics,
6525 XD Nijmegen, The Netherlands.
(4)Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital,
Hartford, CT 06106.
(5)Department of Human Genetics, Donders Institute for Brain, Cognition and
Behaviour, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
(6)Department of Psychiatry, Donders Institute for Brain, Cognition and
Behaviour, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
(7)Institut des Maladies Neurodégénératives, UMR 5293, Groupe d’Imagerie
Neurofonctionnelle, Commissariat à l’énergie atomique et aux énergies
alternatives-CNRS-Université de Bordeaux, 33076 Bordeaux cedex, France.
(8)Donders Institute for Brain, Cognition and Behavior, Radboud University, 6525
EN Nijmegen, The Netherlands.
(9)Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics
Institute, Keck School of Medicine, University of Southern California, Marina del
Rey, CA 90292.
Hemispheric asymmetry is a cardinal feature of human brain organization. Altered
brain asymmetry has also been linked to some cognitive and neuropsychiatric
disorders. Here, the ENIGMA (Enhancing NeuroImaging Genetics through
Meta-Analysis) Consortium presents the largest-ever analysis of cerebral cortical
asymmetry and its variability across individuals. Cortical thickness and surface
area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets
worldwide. Results revealed widespread asymmetries at both hemispheric and
regional levels, with a generally thicker cortex but smaller surface area in the
left hemisphere relative to the right. Regionally, asymmetries of cortical
thickness and/or surface area were found in the inferior frontal gyrus,
transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These
regions are involved in lateralized functions, including language and
visuospatial processing. In addition to population-level asymmetries, variability
in brain asymmetry was related to sex, age, and intracranial volume.
Interestingly, we did not find significant associations between asymmetries and
handedness. Finally, with two independent pedigree datasets (n = 1,443 and 1,113,
respectively), we found several asymmetries showing significant, replicable
heritability. The structural asymmetries identified and their variabilities and
heritability provide a reference resource for future studies on the genetic basis
of brain asymmetry and altered laterality in cognitive, neurological, and
psychiatric disorders.
DOI: 10.1073/pnas.1718418115
PMCID: PMC5984496 [Available on 2018-11-29]
PMID: 29764998
Conflict of interest statement: Conflict of interest statement: B.F. received
educational speaking fees from Merz and Shire. Some ENIGMA members listed in SI
Appendix also declare a conflict of interest. The other authors declare no
conflict of interest.