L-type voltage-dependent Ca2+ channels mediate expression of presynaptic LTP in amygdala
Nat Neurosci. 2009-08-02; 12(9): 1093-1095
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1. Nat Neurosci. 2009 Sep;12(9):1093-5. doi: 10.1038/nn.2378. Epub 2009 Aug 2.
L-type voltage-dependent Ca(2+) channels mediate expression of presynaptic LTP in amygdala.
Fourcaudot E(1), Gambino F, Casassus G, Poulain B, Humeau Y, Lüthi A.
(1)Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
The molecular mechanisms underlying the expression of postsynaptic long-term
potentiation (LTP) at glutamatergic synapses are well understood. However, little
is known about those that mediate the expression of presynaptic LTP. We found
that presynaptic LTP at cortical inputs to the mouse lateral amygdala was blocked
and reversed by L-type voltage-dependent Ca(2+) channel (L-VDCC) blockers. Thus,
a persistent increase in L-VDCC-mediated glutamate release underlies the
expression of presynaptic LTP in the amygdala.
PMID: 19648911 [Indexed for MEDLINE]