Kainate receptor-interacting proteins and membrane trafficking

1. Biochem Soc Trans. 2006 Nov;34(Pt 5):927-30.

Kainate receptor-interacting proteins and membrane trafficking.

Coussen F(1), Mulle C.

Author information:
(1)CNRS UMR 5091, Laboratoire Physiologie Cellulaire de la Synapse, Bordeaux
Neuroscience Institute, University of Bordeaux, 33077 Bordeaux Cedex, France.

Kainate receptors are composed of several subunits and splice variants, but the
relevance of this diversity is still not well understood. The subunits and splice
variants show great divergence in their C-terminal cytoplasmic tail region, which
has been identified as a region of interaction with a number of protein partners.
Differential trafficking of kainate receptors to neuronal compartments is likely
to rely on interactions with distinct subsets of protein partners. This review
summarizes our knowledge of the regulation of trafficking of kainate receptors
and focuses on the identification and characterization of functions of
interacting partners.

DOI: 10.1042/BST0340927
PMID: 17052229 [Indexed for MEDLINE]

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