Juvenile, but not adult exposure to high-fat diet impairs relational memory and hippocampal neurogenesis in mice.
Hippocampus. 2012-05-17; 22(11): 2095-2100
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1. Hippocampus. 2012 Nov;22(11):2095-100. doi: 10.1002/hipo.22032. Epub 2012 May 17.
Juvenile, but not adult exposure to high-fat diet impairs relational memory and
hippocampal neurogenesis in mice.
Boitard C(1), Etchamendy N, Sauvant J, Aubert A, Tronel S, Marighetto A, Layé S,
(1)INRA, Nutrition et Neurobiologie Intégrée, UMR1286, F-33000 Bordeaux, France.
Increased consumption of high-fat diet (HFD) leads to obesity and adverse
neurocognitive outcomes. Childhood and adolescence are important periods of brain
maturation shaping cognitive function. These periods could consequently be
particularly sensitive to the detrimental effects of HFD intake. In mice,
juvenile and adulthood consumption of HFD induce similar morphometric and
metabolic changes. However, only juvenile exposure to HFD abolishes relational
memory flexibility, assessed after initial radial-maze concurrent spatial
discrimination learning, and decreases neurogenesis. Our results identify a
critical period of development covering adolescence with higher sensitivity to
HFD-induced hippocampal dysfunction at both behavioral and cellular levels.
Copyright © 2012 Wiley Periodicals, Inc.
PMID: 22593080 [Indexed for MEDLINE]