Interaction between Neurogenesis and Hippocampal Memory System: New Vistas.
Cold Spring Harb Perspect Biol. 2015-06-01; 7(6): a018952
DOI: 10.1101/cshperspect.a018952
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1. Cold Spring Harb Perspect Biol. 2015 Jun 1;7(6). pii: a018952. doi:
10.1101/cshperspect.a018952.
Interaction between Neurogenesis and Hippocampal Memory System: New Vistas.
Abrous DN(1), Wojtowicz JM(2).
Author information:
(1)Inserm U862, Bordeaux-F33077, France Université de Bordeaux, Bordeaux-F33077,
France.
(2)Department of Physiology, University of Toronto, Medical Sciences Building,
Toronto, Ontario M5S 1A8, Canada.
During the last decade, the questions on the functionality of adult neurogenesis
have changed their emphasis from if to how the adult-born neurons participate in
a variety of memory processes. The emerging answers are complex because we are
overwhelmed by a variety of behavioral tasks that apparently require new neurons
to be performed optimally. With few exceptions, the hippocampal memory system
seems to use the newly generated neurons for multiple roles. Adult neurogenesis
has given the dentate gyrus new capabilities not previously thought possible
within the scope of traditional synaptic plasticity. Looking at these new
developments from the perspective of past discoveries, the science of adult
neurogenesis has emerged from its initial phase of being, first, a surprising
oddity and, later, exciting possibility, to the present state of being an
integral part of mainstream neuroscience. The answers to many remaining questions
regarding adult neurogenesis will come along only with our growing understanding
of the functionality of the brain as a whole. This, in turn, will require
integration of multiple levels of organization from molecules and cells to
circuits and systems, ultimately resulting in comprehension of behavioral
outcomes.
Copyright © 2015 Cold Spring Harbor Laboratory Press; all rights reserved.
DOI: 10.1101/cshperspect.a018952
PMCID: PMC4448601
PMID: 26032718 [Indexed for MEDLINE]