Insult-induced aberrant hippocampal neurogenesis: Functional consequences and possible therapeutic strategies.
Behavioural Brain Research. 2019-10-01; 372: 112032
DOI: 10.1016/j.bbr.2019.112032
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Bielefeld P(1), Durá I(2), Danielewicz J(3), Lucassen PJ(1), Baekelandt V(4),
Abrous DN(5), Encinas JM(6), Fitzsimons CP(7).
Author information:
(1)Swammerdam Institute for Life Science, Faculty of Science, University of
Amsterdam, the Netherlands; University of Bordeaux, 33000 Bordeaux, France.
(2)Achucarro Basque Center for Neuroscience, Spain; University of the Basque
Country (UPV/EHU), Spain; University of Bordeaux, 33000 Bordeaux, France.
(3)Achucarro Basque Center for Neuroscience, Spain; University of Bordeaux, 33000
Bordeaux, France.
(4)KU Leuven, Department of Neurosciences and Leuven Brain Institute, Laboratory
for Neurobiology and Gene Therapy, Belgium; University of Bordeaux, 33000
Bordeaux, France.
(5)INSERM, U1215 NeuroCentre Magendie, 33000 Bordeaux, France; University of
Bordeaux, 33000 Bordeaux, France.
(6)Achucarro Basque Center for Neuroscience, Spain; IKERBASQUE, the Basque
Foundation for Science, Spain; University of the Basque Country (UPV/EHU), Spain;
University of Bordeaux, 33000 Bordeaux, France. Electronic address:
.
(7)Swammerdam Institute for Life Science, Faculty of Science, University of
Amsterdam, the Netherlands; University of Bordeaux, 33000 Bordeaux, France.
Electronic address: .
Adult hippocampal neurogenesis plays a critical role in a wide spectrum of
hippocampus-dependent functions. Brain pathologies that involve the hippocampus
like epilepsy, stroke, and traumatic brain injury, are commonly associated with
cognitive impairments and mood disorders. These insults can affect neural stem
cells and the subsequent neurogenic cascade in the hippocampus, resulting in the
induction of aberrant neurogenesis, which is thought to compromise hippocampal
network function, thereby hampering hippocampus-dependent behavior. We here
summarize recent preclinical literature on hippocampal insult-induced changes in
neurogenesis and based on that, we propose that normalizing aberrant neurogenesis
post-insult may help to prevent or rescue behavioral deficits which could help
develop novel therapeutic strategies.