Inhibition of PDZ domain-mediated interactions

Dolors Grillo-Bosch, Daniel Choquet, Matthieu Sainlos
Drug Discovery Today: Technologies. 2013-12-01; 10(4): e531-e540
DOI: 10.1016/j.ddtec.2012.10.003

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1. Drug Discov Today Technol. 2013 Dec;10(4):e531-40. doi:

Inhibition of PDZ domain-mediated interactions.

Grillo-Bosch D, Choquet D, Sainlos M.

Modulating protein-protein interactions constitutes a promising strategy both for
the investigation of biological mechanisms and for developing new therapeutic
approaches. Among the many types of inter-actions, PDZ domain-mediated
interactions (PDMIs) have emerged over the last decade as attractive targets in
the drug discovery field. Indeed, these small domains are involved in the
regulation of many signaling pathways and possess structural properties which are
favorable for the design of competing ligands. Herein, we describe the recent
approaches developed to inhibit this class of protein-protein interactions.

DOI: 10.1016/j.ddtec.2012.10.003
PMID: 24451645 [Indexed for MEDLINE]

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