Ilex paraguariensis extends lifespan and increases an ability to resist environmental stresses in drosophila
Rejuvenation Research. 2018-12-01; 21(6): 497-505
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1. Rejuvenation Res. 2018 Dec;21(6):497-505. doi: 10.1089/rej.2017.2023. Epub 2018
Ilex paraguariensis Extends Lifespan and Increases an Ability to Resist
Environmental Stresses in Drosophila.
Niraula P(1), Ghimire S(1), Lee H(1), Kim MS(1)(2).
(1)1 College of Pharmacy, Department of Pharmacy, Inje University, Gimhae,
Republic of Korea.
(2)2 Inje Institute of Pharmaceutical Sciences and Research, Inje University,
Gimhae, Republic of Korea.
Aging is a complex process resulting in (1) a decline in body functions and
capacity to withstand environmental stress and (2) an increased susceptibility to
diseases including, but not limited to, cardiovascular disorders, diabetes,
cancer, and dementia. Among a number of herbal products used to alleviate
symptoms associated with aging is Ilex paraguariensis (IP). This product has been
reported to have anticancer, anti-inflammatory, and antioxidant activities.
However, its effect on an organisms’ longevity has not been thoroughly studied to
date. Here, we report that 10 mg/mL IP supplementation significantly extended the
lifespan of Drosophila. Additionally, IP enhanced flies’ ability to resist
environmental stress as estimated using starvation, paraquat, and desiccation
assays. Additional experiments revealed insignificant changes in weight gain,
physical activity, and metabolic profiles such as levels of water, lipid, and
protein in flies receiving IP supplementation. Rather, levels of messenger RNA
for enzymes that scavenge reactive oxygen species (i.e., superoxide dismutases,
catalase, and glutathione peroxidase) were found to be significantly altered
despite subtle changes in their catalytic activities. We hope that our research
demonstrating IP-induced lifespan extension and related biological mechanisms of
this interesting phenomenon will encourage further studies, which may eventually
determine whether IP has utility as a novel antiaging agent.
PMID: 29756514 [Indexed for MEDLINE]