Identification and treatment of symptoms associated with inflammation in medically ill patients.

Robert Dantzer, Lucile Capuron, Michael R. Irwin, Andrew H. Miller, Helene Ollat, Victor Hugh Perry, Sarah Rousey, Raz Yirmiya
Psychoneuroendocrinology. 2008-01-01; 33(1): 18-29
DOI: 10.1016/j.psyneuen.2007.10.008

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1. Psychoneuroendocrinology. 2008 Jan;33(1):18-29. Epub 2007 Dec 3.

Identification and treatment of symptoms associated with inflammation in
medically ill patients.

Dantzer R(1), Capuron L, Irwin MR, Miller AH, Ollat H, Perry VH, Rousey S,
Yirmiya R.

Author information:
(1)Integrative Immunology and Behavior Program, 212 ERML, 1201 W Gregory Drive,
University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

Medically ill patients present with a high prevalence of non-specific comorbid
symptoms including pain, sleep disorders, fatigue and cognitive and mood
alterations that is a leading cause of disability. However, despite major
advances in the understanding of the immune-to-brain communication pathways that
underlie the pathophysiology of these symptoms in inflammatory conditions, little
has been done to translate this newly acquired knowledge to the clinics and to
identify appropriate therapies. In a multidisciplinary effort to address this
problem, clinicians and basic scientists with expertise in areas of inflammation,
psychiatry, neurosciences and psychoneuroimmunology were brought together in a
specialized meeting organized in Bordeaux, France, on May 28-29, 2007. These
experts considered key questions in the field, in particular those related to
identification and quantification of the predominant symptoms associated with
inflammation, definition of systemic and central markers of inflammation,
possible domains of intervention for controlling inflammation-associated
symptoms, and relevance of animal models of inflammation-associated symptoms.
This resulted in a number of recommendations that should improve the recognition
and management of inflammation-associated symptoms in medically ill patients.

DOI: 10.1016/j.psyneuen.2007.10.008
PMCID: PMC2234599
PMID: 18061362 [Indexed for MEDLINE]

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