Identifiability analysis and parameter identification of an in vivo ligand-receptor model from PET data
IEEE Trans. Biomed. Eng.. 1990-07-01; 37(7): 653-661
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1. IEEE Trans Biomed Eng. 1990 Jul;37(7):653-61.
Identifiability analysis and parameter identification of an in vivo
ligand-receptor model from PET data.
Delforge J(1), Syrota A, Mazoyer BM.
(1)Service Hospitalier Frédéric Joliot, Hôpital d’Orsay, France.
Identifiability problem is a very important topic in the framework of model
justification and not accounting for it during the modeling procedure can lead to
meaningless results. While studying the receptor-ligand model parameter
estimation from dynamic positron emission tomography data, each of the three
possible conclusions to the identifiability problem (i.e., unidentifiable model,
multiple solutions, or unique solution) are reached depending on the experimental
protocol used. The identification of the model parameters from data obtained with
a single tracer injection leads to disappointing numerical results since most of
the parameters have to be considered as unidentifiable. A protocol including two
injections, a first injection of the labeled ligand and a second injection of the
cold ligand (displacement experiment) leads to two very different numerical
solutions, which is surprising since such multiplicity of solutions was not
indicated by a preliminary theoretical identifiability study. We show that a
three-injections protocol, including both a displacement and coinjection
experiment, allows to determine which of these two solutions is biologically
PMID: 2394453 [Indexed for MEDLINE]