Hypothalamic leptin action is mediated by histone deacetylase 5.

Kabra D.G., Pfuhlmann K., García-Cáceres C., Schriever S.C., Casquero García V., Kebede A.F., Fuente-Martin E., Trivedi C., Heppner K., Uhlenhaut N.H., Legutko B., Kabra U.D., Gao Y., Yi C.X., Quarta C., Clemmensen C., Finan B., Müller T.D, Meyer C.W., Paez-Pereda M., Stemmer K., Woods S.C., Perez-Tilve D., Schneider R., Olson E.N., Tschöp M.H., Pfluger P.T.
Nature Commun. 2016-02-29; 7: 10782
DOI: 10.1038/ncomms10782

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