How to trace stem cells for MRI evaluation?
Journal of the Neurological Sciences. 2008-02-01; 265(1-2): 122-126
DOI: 10.1016/j.jns.2007.09.026
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1. J Neurol Sci. 2008 Feb 15;265(1-2):122-6. Epub 2007 Oct 25.
How to trace stem cells for MRI evaluation?
Dousset V(1), Tourdias T, Brochet B, Boiziau C, Petry KG.
Author information:
(1)Laboratoire de Neurobiologie des Affections de la Myéline EA 2966 Université
Victor Segalen Bordeaux 2, 146 rue Léo Saignat 33076 Bordeaux, France.
Applications of imaging techniques to visualize stem cells for monitoring,
control and treatment of biological systems, in particular the brain, is at the
forefront of investigations. These approaches involve the identification of stem
and precursor cells that may be of various origins, but are related to specific
clinical conditions, and the choice of the appropriate markers to achieve the
required imaging while minimizing the side effects. This article will review
examples of the contrast agent design for rational approaches in stem cell
imaging. Potential pitfalls or side effects associated with contrast agents, in
particular iron oxide nanoparticles, for cell labelling are also discussed.
DOI: 10.1016/j.jns.2007.09.026
PMID: 17963784 [Indexed for MEDLINE]