High-Performance Implantable Sensors based on Anisotropic Magnetoresistive La0.67Sr0.33MnO3 for Biomedical Applications

Arturo Vera, Isidoro Martínez, Luiz Guilherme Enger, Bruno Guillet, Rubén Guerrero, José Manuel Diez, Olivier Rousseau, Marc Lam Chok Sing, Victor Pierron, Paolo Perna, Jaime J. Hernández, Isabel Rodríguez, Ivo Calaresu, Anja Meier, Carmen Huck, Ana Domínguez-Bajo, Ankor González-Mayorga, Elisa López-Dolado, María C. Serrano, Laura Ballerini, Lucas Pérez, Rodolfo Miranda, Stéphane Flament, María Teresa González, Laurence Méchin, Julio Camarero
ACS Biomater. Sci. Eng.. 2023-01-31; :
DOI: 10.1021/acsbiomaterials.2c01147

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Vera A(1), Martínez I(1)(2), Enger LG(3), Guillet B(3), Guerrero R(1), Diez JM(1)(4), Rousseau O(3), Lam Chok Sing M(3), Pierron V(3), Perna P(1), Hernández JJ(1), Rodríguez I(1), Calaresu I(5), Meier A(6), Huck C(6), Domínguez-Bajo A(7), González-Mayorga A(8), López-Dolado E(8)(9), Serrano MC(7), Ballerini L(5), Pérez L(1)(10), Miranda R(1)(4)(11), Flament S(3), González MT(1), Méchin L(3), Camarero J(1)(4)(11).

Author information:
(1)Fundación IMDEA Nanociencia, Calle Faraday 9, Madrid 28049, Spain.
(2)Faculty of Experimental Sciences, Universidad Francisco de Vitoria, Pozuelo
de Alarcón, Madrid 28223, Spain.
(3)Normandie University, UNICAEN, ENSICAEN, CNRS, GREYC, Caen 14000, France.
(4)Departamento Física de la Materia Condensada, Universidad Autónoma de Madrid,
Madrid 28049, Spain.
(5)International School for Advanced Studies (SISSA/ISAS), Via Bonomea 265,
Trieste 34136, Italy.
(6)mfd-Diagnostics GmbH, Mikroforum Ring 5, Wendelsheim 55234, Germany.
(7)Instituto de Ciencia de Materiales de Madrid (ICMM), CSIC, Calle Sor Juana
Inés de la Cruz 3, Madrid 28049, Spain.
(8)Hospital Nacional de Parapléjicos, SESCAM, Finca La Peraleda s/n, Toledo
45071, Spain.
(9)Research Unit of “Design and Development of Biomaterials for Neural
Regeneration”, Hospital Nacional de Parapléjicos, Joint Research Unit with CSIC,
Toledo 45071, Spain.
(10)Dept. Física de Materiales, Universidad Complutense, Madrid 28040, Spain.
(11)Instituto “Nicolás Cabrera” and Condensed Matter Physics Center (IFIMAC),
Universidad Autónoma de Madrid, Madrid 28049, Spain.

We present the design, fabrication, and characterization of an implantable
neural interface based on anisotropic magnetoresistive (AMR) magnetic-field
sensors that combine reduced size and high performance at body temperature. The
sensors are based on La0.67Sr0.33MnO3 (LSMO) as a ferromagnetic material, whose
epitaxial growth has been suitably engineered to get uniaxial anisotropy and
large AMR output together with low noise even at low frequencies. The
performance of LSMO sensors of different film thickness and at different
temperatures close to 37 °C has to be explored to find an optimum sensitivity of
∼400%/T (with typical detectivity values of 2 nT·Hz-1/2 at a frequency of 1 Hz
and 0.3 nT·Hz-1/2 at 1 kHz), fitted for the detection of low magnetic signals
coming from neural activity. Biocompatibility tests of devices consisting of
submillimeter-size LSMO sensors coated by a thin poly(dimethyl siloxane)
polymeric layer, both in vitro and in vivo, support their high suitability as
implantable detectors of low-frequency biological magnetic signals emerging from
heterogeneous electrically active tissues.


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