High-frequency stimulation of the sub-thalamic nucleus suppresses absence seizures in the rat: Comparison with neurotoxic lesions

L Vercueil, A Benazzouz, C Deransart, K Bressand, C Marescaux, A Depaulis, A.L Benabid
Epilepsy Research. 1998-06-01; 31(1): 39-46
DOI: 10.1016/S0920-1211(98)00011-4

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1. Epilepsy Res. 1998 Jun;31(1):39-46. doi: 10.1016/s0920-1211(98)00011-4.

High-frequency stimulation of the subthalamic nucleus suppresses absence
seizures in the rat: comparison with neurotoxic lesions.

Vercueil L(1), Benazzouz A, Deransart C, Bressand K, Marescaux C, Depaulis A,
Benabid AL.

Author information:
(1)U398 INSERM, Faculté de Médecine, Strasbourg, France.

High-frequency electrical stimulation of deep brain structures has recently been
developed for the surgical approach of neurologic disorders. Applied to the
thalamus in tremors or to the subthalamic nucleus in Parkinson’s disease,
high-frequency stimulation has been demonstrated to exert a local inhibiting
influence, leading to symptoms alleviation. In the present study, bilateral
high-frequency stimulations (130 Hz) of the subthalamic nuclei suppressed
ongoing spontaneous absence seizures in rats. This effect was dissociated from
motor side-effects and appears specific to the subthalamic nucleus. Bilateral
excitotoxic lesions of the subthalamic nuclei only partially suppressed
absence-seizures. These results confirm the involvement of the basal ganglia
system in the control of generalized seizures and suggest that high-frequency
stimulations could be used in the treatment of some forms of seizures.

DOI: 10.1016/s0920-1211(98)00011-4
PMID: 9696299 [Indexed for MEDLINE]

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