High frequency of poor locomotor performance in HIV-infected patients.

Laura Richert, Patrick Dehail, Patrick Mercié, Frédéric-Antoine Dauchy, Mathias Bruyand, Carine Greib, François Dabis, Fabrice Bonnet, Geneviève Chêne
AIDS. 2011-03-01; 25(6): 797-805
DOI: 10.1097/qad.0b013e3283455dff

Read on PubMed

1. AIDS. 2011 Mar 27;25(6):797-805. doi: 10.1097/QAD.0b013e3283455dff.

High frequency of poor locomotor performance in HIV-infected patients.

Richert L(1), Dehail P, Mercié P, Dauchy FA, Bruyand M, Greib C, Dabis F, Bonnet
F, Chêne G; Groupe d’Epidémiologie Clinique du SIDA en Aquitaine (GECSA).

Collaborators: Allard M, Amieva H, Auriacombe M, Auriacombe S, Bestaven E, Bonnet
F, Bruyand M, Catheline G, Chêne G, Coldefy G, Dabis F, Dartigues JF, Dauchy FA,
Delveaux S, Dehail P, Greib C, Lewden C, Macua J, Marquant F, Matharan F, Mercié
P, Milien C, Morlat P, Raoux N, Richert L.

Author information:
(1)INSERM U, Université Bordeaux Segalen, France.

Comment in
AIDS. 2011 Jun 1;25(9):1227.

OBJECTIVES: To provide up-to-date assessments of locomotor function in
HIV-infected patients and to identify potential determinants of impaired
DESIGN: Cross-sectional study in 324 HIV-1-infected adults from the French Agency
for AIDS and Hepatitis Research (ANRS) CO3 Aquitaine Cohort using standardized
locomotor tests.
METHODS: Patients underwent standardized testing assessing balance, walking
ability, functional capacity and lower limb muscle performance. Poor test
performance was defined by cut-offs based on age-specific data of the general
population. Factors associated with poor test performance were studied by
logistic regression.
RESULTS: Median age was 48 years, 80% were men and 89% were on antiretroviral
treatment. The most frequently altered locomotor test was the five-times
sit-to-stand (5STS) test, assessing lower limb muscle performance (poor
performance: 53%). In multivariable analysis, time since HIV diagnosis was
associated with poor 5STS performance [odds ratio (OR) = 1.08 per year; 95%
confidence interval (CI): 1.03, 1.13]. In patients below 30 years, elevated BMI
was associated with higher likelihood of good performance (OR = 0.81 per kg/m(2);
95% CI: 0.69, 0.93), whereas in those above 70 years this association was
reversed (OR = 1.30 per kg/m(2); 95% CI: 1.10, 1.53; P < 10(-3) for interaction).
We found no association with antiretroviral treatment.
CONCLUSION: One of two adults with controlled HIV infection had poor lower limb
muscle performance, which might put this population at risk of falls and
fracture. The 5STS test is a simple test that should be recommended to assess
muscular performance in HIV care.

DOI: 10.1097/QAD.0b013e3283455dff
PMID: 21330905 [Indexed for MEDLINE]

Know more about