Hemodynamic, autonomic and baroreflex changes after one night sleep deprivation in healthy volunteers

Massimo Pagani, Paolo Pizzinelli, Anne Pavy-Le Traon, Cinzia Ferreri, Silvia Beltrami, Marie-Pierre Bareille, Marie-Claude Costes-Salon, Stéphane Béroud, Olivier Blin, Daniela Lucini, Pierre Philip
Autonomic Neuroscience. 2009-01-01; 145(1-2): 76-80
DOI: 10.1016/j.autneu.2008.10.009

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1. Auton Neurosci. 2009 Jan 28;145(1-2):76-80. doi: 10.1016/j.autneu.2008.10.009.
Epub 2008 Nov 8.

Hemodynamic, autonomic and baroreflex changes after one night sleep deprivation
in healthy volunteers.

Pagani M(1), Pizzinelli P, Traon AP, Ferreri C, Beltrami S, Bareille MP,
Costes-Salon MC, Béroud S, Blin O, Lucini D, Philip P.

Author information:
(1)Centro di Ricerca sulla Terapia Neurovegetativa, Dipartimento Scienze Cliniche
L. Sacco, University of Milano, Milano, Italy.

BACKGROUND: Sleep disorders are associated to a number of cardiovascular
disturbances that might increase cardiovascular risk. Sleep deprivation, in
particular, might, by inducing autonomic dysregulation, raise arterial pressure
and hypertensive risk. Available evidence however is contradictory.
METHODS: We tested the main hypothesis that one night sleep deprivation in 24
volunteers might alter hemodynamics (heart rate and Arterial Pressure – AP),
autonomic regulation (mono and bivariate spectral analysis of RR and non invasive
AP variability) and baroreflex control (spectral index alpha and spontaneous
baroreflex slope), performance indices (reaction time) and subjective stress
(questionnaires and salivary cortisol). Volunteers were studied in normal living
conditions and while kept in isolation and confinement, to test the presence of
possible bias related to environmental stress.
RESULTS: Results indicate that there were no differences between normal living
conditions and isolation and confinement (Intraclass Correlation Coefficient
>0.75 for most variables). Conversely, after one night sleep deprivation subjects
felt tired (p

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