Genotype-phenotype associations in understanding the role of corticosteroid-binding globulin in health and disease animal models.
Molecular and Cellular Endocrinology. 2010-03-01; 316(1): 35-41
DOI: 10.1016/j.mce.2009.07.017
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1. Mol Cell Endocrinol. 2010 Mar 5;316(1):35-41. doi: 10.1016/j.mce.2009.07.017.
Epub 2009 Jul 28.
Genotype-phenotype associations in understanding the role of
corticosteroid-binding globulin in health and disease animal models.
Moisan MP(1).
Author information:
(1)INRA, UMR 1286 PsyNuGen, CNRS 5226, Universite de Bordeaux 2, Bordeaux,
France.
Corticosteroid-binding globulin (CBG) is a plasma glycoprotein discovered more
than 60 years ago for its high-affinity for glucocorticoids. Although its
molecular structure and its biochemical properties have been described, its
various biological roles and its importance are not yet fully understood. This
review focuses first on studies that have used no-hypothesis-driven genetic
approaches in animal models to reveal the higher than expected importance of CBG
in particular in glucocorticoid stress responses. Then the dissection of some CBG
physiological roles in an animal model of genetic CBG deficiency is reported.
Finally, studies on the role of CBG genetic variability in human obesity traits
are reviewed and discussed.
2009 Elsevier Ireland Ltd. All rights reserved.
DOI: 10.1016/j.mce.2009.07.017
PMID: 19643164 [Indexed for MEDLINE]