Gating and permeation of kainate receptors: differences unveiled.
Trends in Pharmacological Sciences. 2010-11-01; 31(11): 516-522
DOI: 10.1016/j.tips.2010.08.004
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1. Trends Pharmacol Sci. 2010 Nov;31(11):516-22. doi: 10.1016/j.tips.2010.08.004.
Epub 2010 Sep 16.
Gating and permeation of kainate receptors: differences unveiled.
Perrais D(1), Veran J, Mulle C.
Author information:
(1)Laboratoire Physiologie Cellulaire de la Synapse, CNRS UMR 5091, University of
Bordeaux, 33077 Bordeaux, France.
Kainate receptors (KARs) represent, together with
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl
D-aspartate (NMDA) receptors, one of the three families of ionotropic glutamate
receptors. Recent advances in the study of their biophysical properties have
revealed a surprising diversity. KAR-mediated excitatory postsynaptic currents
(EPSCs) are often much slower than AMPA receptor-mediated EPSCs, and this is
probably due to the slow deactivation rate of KARs containing the GluK4 or GluK5
subunits. By contrast, GluK3-containing receptors, unlike other AMPA/kainate
receptors, desensitize faster at low agonist concentrations, making these
receptors insensitive to glutamate spillover from neighboring synapses. Moreover,
KARs have a wide range of sensitivities to intracellular polyamines and
consequently of voltage dependent activation. Finally, newly discovered
associated proteins, such as Neto1 and 2, have marked effects on receptor
properties, increasing further the potential diversity of KAR functional
properties. Altogether, this functional diversity of KARs could have profound
consequences on their ability to shape synaptic transmission under physiological
and pathological conditions.
Copyright © 2010 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.tips.2010.08.004
PMID: 20850188 [Indexed for MEDLINE]