Functional segregation and integration within fronto-parietal networks
NeuroImage. 2017-02-01; 146: 367-375
DOI: 10.1016/j.neuroimage.2016.08.031
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1. Neuroimage. 2017 Feb 1;146:367-375. doi: 10.1016/j.neuroimage.2016.08.031. Epub
2016 Sep 14.
Functional segregation and integration within fronto-parietal networks.
Parlatini V(1), Radua J(2), Dell’Acqua F(3), Leslie A(3), Simmons A(4), Murphy
DG(5), Catani M(6), Thiebaut de Schotten M(7).
Author information:
(1)Sackler Institute of Translational Neurodevelopment, Department of Forensic
and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and
Neuroscience, King’s College London, SE5 8AF London, UK; Natbrainlab, Department
of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology
and Neuroscience, King’s College London, SE5 8AF London, UK. Electronic address:
.
(2)Department of Psychosis Studies, Institute of Psychiatry, Psychology and
Neuroscience, King’s College London, SE5 8AF London, UK; FIDMAG Germanes
Hospitalàries, CIBERSAM, Sant Boi de Llobregat 08035, Spain.
(3)Natbrainlab, Department of Forensic and Neurodevelopmental Sciences, Institute
of Psychiatry, Psychology and Neuroscience, King’s College London, SE5 8AF
London, UK; Department of Neuroimaging, Institute of Psychiatry, Psychology and
Neuroscience, King’s College London, SE5 8AF London, UK; NIHR Biomedical Research
Centre for Mental Health at South London and Maudsley NHS Foundation Trust and
King’s College London, Institute of Psychiatry, SE5 8AF London, UK.
(4)Department of Neuroimaging, Institute of Psychiatry, Psychology and
Neuroscience, King’s College London, SE5 8AF London, UK; NIHR Biomedical Research
Centre for Mental Health at South London and Maudsley NHS Foundation Trust and
King’s College London, Institute of Psychiatry, SE5 8AF London, UK; MRC Centre
for Neurodegeneration Research, King’s College London, SE5 9RX London, UK.
(5)Sackler Institute of Translational Neurodevelopment, Department of Forensic
and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and
Neuroscience, King’s College London, SE5 8AF London, UK.
(6)Sackler Institute of Translational Neurodevelopment, Department of Forensic
and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and
Neuroscience, King’s College London, SE5 8AF London, UK; Natbrainlab, Department
of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology
and Neuroscience, King’s College London, SE5 8AF London, UK.
(7)Sackler Institute of Translational Neurodevelopment, Department of Forensic
and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and
Neuroscience, King’s College London, SE5 8AF London, UK; Natbrainlab, Department
of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology
and Neuroscience, King’s College London, SE5 8AF London, UK; Brain Connectivity
Behaviour group, FrontLab, Paris, France; Sorbonne Universités, UPMC Univ Paris
06, Inserm, CNRS, Institut du cerveau et la moelle (ICM) – Hôpital
Pitié-Salpêtrière, Boulevard de l’hôpital, F-75013, Paris, France. Electronic
address: .
Experimental data on monkeys and functional studies in humans support the
existence of a complex fronto-parietal system activating for cognitive and motor
tasks, which may be anatomically supported by the superior longitudinal
fasciculus (SLF). Advanced tractography methods have recently allowed the
separation of the three branches of the SLF but are not suitable for their
functional investigation. In order to gather comprehensive information about the
functional organisation of these fronto-parietal connections, we used an
innovative method, which combined tractography of the SLF in the largest dataset
so far (129 participants) with 14 meta-analyses of functional magnetic resonance
imaging (fMRI) studies. We found that frontal and parietal functions can be
clustered into a dorsal spatial/motor network associated with the SLF I, and a
ventral non-spatial/motor network associated with the SLF III. Further, all the
investigated functions activated a middle network mostly associated with the SLF
II. Our findings suggest that dorsal and ventral fronto-parietal networks are
segregated but also share regions of activation, which may support flexible
response properties or conscious processing. In sum, our novel combined approach
provided novel findings on the functional organisation of fronto-parietal
networks, and may be successfully applied to other brain connections.
Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.
DOI: 10.1016/j.neuroimage.2016.08.031
PMCID: PMC5312783
PMID: 27639357 [Indexed for MEDLINE]