Frailty and Brain-Muscle Correlates in Older People With Type 2 Diabetes: A structural-MRI Explorative Study.
J Nutr Health Aging. 2019-07-01; 23(7): 637-640
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1. J Nutr Health Aging. 2019;23(7):637-640. doi: 10.1007/s12603-019-1229-3.
Frailty and Brain-Muscle Correlates in Older People With Type 2 Diabetes: A
structural-MRI Explorative Study.
Bourdel-Marchasson I(1), Catheline G, Regueme S, Danet-Lamasou M, Barse E,
Ratsimbazafy F, Rodriguez-Manas L, Hood K, Sinclair AJ.
(1)I Bourdel-Marchasson, CNRS/Université de Bordeaux, UMR 5536 Résonance
Magnétique des systèmes Biologiques, Bordeaux, France,
OBJECTIVES: Muscle alterations, mainly functional alterations are frequently
observed in older people with type 2 diabetes (T2DM). Sarcopenia may be one
mechanism of transition to frailty in these people. Thus, we aim to explore the
characteristics of muscle and its association with cerebral grey matter volumes
within this group.
METHODS: Single center study nested within the international MID-Frail (a
randomized clinical trial to evaluate the effectiveness of a multi-modal
intervention in older people with T2DM on frailty and quality of life) trial
participants underwent both brain and muscle T1 MRI, nutritional and functional
assessments. Muscle areas were measured in rectus femoris (RF). Relationships
between MRI grey matter volumes and muscle areas or function tests were described
using positive and negative regressions.
RESULTS: Twenty-six subjects (7 female, mean age 78.2 y, SD 5.0), 6 frail and 20
pre-frail were explored in this sub-study. Frail subjects had lower Mini
Nutritional Assessment (MNA), Short Physical Performance Battery (SPPB), hip
flexor strength than pre-frail ones but similar BMI and balance. Total SPPB was
positively related with hip flexor strength and maximal RF area. Balance SPPB
sub-score was unrelated to strength or RF area. MNA score was correlated with hip
flexor strength and to global grey matter but not to SPPB. Hip flexor strength
was correlated with grey matter areas involved in motor control. Walking time was
negatively and rising chair sub-score was positively associated with grey matter
volumes of motor areas.
CONCLUSIONS: Sarcopenia features were more frequent in frail than prefrail
subjects and were associated with decrease in grey matter volumes involved in
PMID: 31367728 [Indexed for MEDLINE]
Conflict of interest statement: European Commission EU 7th Framework Programme
(Contract Nº 278803) funded the project; none of the authors have any conflict of
interest to declare.