Forebrain structures specifically activated by conditioned taste aversion.
Behavioral Neuroscience. 2006-01-01; 120(4): 952-962
DOI: 10.1037/0735-7044.120.4.952
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1. Behav Neurosci. 2006 Aug;120(4):952-62.
Forebrain structures specifically activated by conditioned taste aversion.
Ferreira G(1), Ferry B, Meurisse M, Lévy F.
Author information:
(1)Laboratoire Comportement, Neurobiologie et Adaptation, UMR 6175
INRA-CNRS-Universite de Tours-Haras Nationaux, Nouzilly, France.
This study investigates which forebrain structures show Fos protein expression
during conditioned taste aversion (CTA) acquisition and whether Fos expression
depends on the aversion strength. A novel taste paired with an intraperitoneal
injection of a low dose of the malaise-inducing agent lithium chloride (LiCl)
induced a weak CTA, whereas associating this novel taste with a high dose of LiCl
induced a strong CTA. Increasing the strength of the gastric malaise alone
enhanced Fos expression in central, basal, and lateral amygdala nuclei and
decreased Fos expression in the nucleus accumbens core. Taste-malaise association
induced specific Fos activation in the insular cortex (with both the low and the
high doses of LiCl) and the nucleus accumbens shell (with the high LiCl dose
only). No significant variation of Fos expression was measured in the perirhinal
cortex. Several forebrain areas may be sites of taste-malaise convergence during
CTA acquisition depending on the strength of the aversion.
DOI: 10.1037/0735-7044.120.4.952
PMID: 16893300 [Indexed for MEDLINE]