Facilitation of Contextual Fear Extinction by Orexin-1 Receptor Antagonism Is Associated with the Activation of Specific Amygdala Cell Subpopulations.
International Journal of Neuropsychopharmacology. 2017-04-27; 20(8): 654-659
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1. Int J Neuropsychopharmacol. 2017 Aug 1;20(8):654-659. doi: 10.1093/ijnp/pyx029.
Facilitation of Contextual Fear Extinction by Orexin-1 Receptor Antagonism Is
Associated with the Activation of Specific Amygdala Cell Subpopulations.
Flores Á(1), Herry C(1), Maldonado R(1), Berrendero F(1).
(1)Laboratory of Neuropharmacology, Department of Experimental and Health
Sciences, Universitat Pompeu Fabra, Barcelona, Spain (Drs Flores, Maldonado, and
Berrendero); INSERM, Neurocentre Magendie, Bordeaux, France (Dr Herry);
University Bordeaux, Neurocentre Magendie, Bordeaux, France (Dr Herry); Faculty
of Experimental Sciences, Universidad Francisco de Vitoria, Madrid, Spain (Dr
Background: Orexins are hypothalamic neuropeptides recently involved in the
regulation of emotional memory. The basolateral amygdala, an area orchestrating
fear memory processes, appears to be modulated by orexin transmission during fear
extinction. However, the neuronal types within the basolateral amygdala involved
in this modulation remain to be elucidated.
Methods: We used retrograde tracing combined with immunofluorescence techniques
in mice to identify basolateral amygdala projection neurons and cell
subpopulations in this brain region influenced by orexin transmission during
contextual fear extinction consolidation.
Results: Treatment with the orexin-1 receptor antagonist SB334867 increased the
activity of basolateral amygdala neurons projecting to infralimbic medial
prefrontal cortex during fear extinction. GABAergic interneurons expressing
calbindin, but not parvalbumin, were also activated by orexin-1 receptor
antagonism in the basolateral amygdala.
Conclusions: These data identify neuronal circuits and cell populations of the
amygdala associated with the facilitation of fear extinction consolidation
induced by the orexin-1 receptor antagonist SB334867.
© The Author 2017. Published by Oxford University Press on behalf of CINP.
PMID: 28453642 [Indexed for MEDLINE]