Evidence for galanin receptors in primary sensory neurones and effect of axotomy and inflammation
NeuroReport. 1996-12-01; 8(1): 237-242
DOI: 10.1097/00001756-199612200-00048
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1. Neuroreport. 1996 Dec 20;8(1):237-42.
Evidence for galanin receptors in primary sensory neurones and effect of axotomy
and inflammation.
Xu ZQ(1), Shi TJ, Landry M, Hökfelt T.
Author information:
(1)Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Using in situ hybridization, mRNA coding for the galanin R1 receptor (GAL-R1) was
demonstrated in > 20% of all lumbar 4 and 5 dorsal root ganglion neurone
profiles, mainly constituting small and medium sized neurones. Almost all of
these neurones expressed CGRP mRNA as revealed by analysis of adjacent sections
and of the same section using a double-labelling technique. GAL-R1 mRNA levels
were down-regulated transiently by inflammation, and more strongly by peripheral
nerve injury. These results suggest that DRG neurones are sensitive to galanin
and that GAL-R1 receptors are involved in sensory processing.
DOI: 10.1097/00001756-199612200-00048
PMID: 9051788 [Indexed for MEDLINE]